IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v10y2019i1d10.1038_s41467-019-10136-w.html
   My bibliography  Save this article

Ubiquitylome study identifies increased histone 2A ubiquitylation as an evolutionarily conserved aging biomarker

Author

Listed:
  • Lu Yang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Zaijun Ma

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Han Wang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Kongyan Niu

    (Chinese Academy of Sciences)

  • Ye Cao

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Le Sun

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Yang Geng

    (Chinese Academy of Sciences)

  • Bo Yang

    (Chinese Academy of Sciences
    East China Normal University)

  • Feng Gao

    (University of Science and Technology of China)

  • Zuolong Chen

    (University of Science and Technology of China)

  • Zhen Wu

    (Fudan University)

  • Qingqing Li

    (Fudan University)

  • Yong Shen

    (University of Science and Technology of China)

  • Xumin Zhang

    (Fudan University)

  • Hong Jiang

    (Chinese Academy of Sciences)

  • Yelin Chen

    (Chinese Academy of Sciences)

  • Rui Liu

    (Singlera Genomics)

  • Nan Liu

    (Chinese Academy of Sciences)

  • Yaoyang Zhang

    (Chinese Academy of Sciences)

Abstract

The long-lived proteome constitutes a pool of exceptionally stable proteins with limited turnover. Previous studies on ubiquitin-mediated protein degradation primarily focused on relatively short-lived proteins; how ubiquitylation modifies the long-lived proteome and its regulatory effect on adult lifespan is unclear. Here we profile the age-dependent dynamics of long-lived proteomes in Drosophila by mass spectrometry using stable isotope switching coupled with antibody-enriched ubiquitylome analysis. Our data describe landscapes of long-lived proteins in somatic and reproductive tissues of Drosophila during adult lifespan, and reveal a preferential ubiquitylation of older long-lived proteins. We identify an age-modulated increase of ubiquitylation on long-lived histone 2A protein in Drosophila, which is evolutionarily conserved in mouse, monkey, and human. A reduction of ubiquitylated histone 2A in mutant flies is associated with longevity and healthy lifespan. Together, our data reveal an evolutionarily conserved biomarker of aging that links epigenetic modulation of the long-lived histone protein to lifespan.

Suggested Citation

  • Lu Yang & Zaijun Ma & Han Wang & Kongyan Niu & Ye Cao & Le Sun & Yang Geng & Bo Yang & Feng Gao & Zuolong Chen & Zhen Wu & Qingqing Li & Yong Shen & Xumin Zhang & Hong Jiang & Yelin Chen & Rui Liu & N, 2019. "Ubiquitylome study identifies increased histone 2A ubiquitylation as an evolutionarily conserved aging biomarker," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10136-w
    DOI: 10.1038/s41467-019-10136-w
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-019-10136-w
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-019-10136-w?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10136-w. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.