IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v10y2019i1d10.1038_s41467-019-10121-3.html
   My bibliography  Save this article

Genomic structure and diversity of Plasmodium falciparum in Southeast Asia reveal recent parasite migration patterns

Author

Listed:
  • Amol C. Shetty

    (University of Maryland School of Medicine
    University of Maryland School of Medicine)

  • Christopher G. Jacob

    (Wellcome Sanger Institute)

  • Fang Huang

    (National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention)

  • Yao Li

    (University of Maryland)

  • Sonia Agrawal

    (University of Maryland School of Medicine
    University of Maryland School of Medicine)

  • David L. Saunders

    (Armed Forces Research Institute of Medical Sciences)

  • Chanthap Lon

    (Armed Forces Research Institute of Medical Sciences)

  • Mark M. Fukuda

    (Armed Forces Research Institute of Medical Sciences)

  • Pascal Ringwald

    (World Health Organization)

  • Elizabeth A. Ashley

    (Mahidol University
    University of Oxford)

  • Kay Thwe Han

    (Ministry of Health and Sports)

  • Tin Maung Hlaing

    (Defence Services Medical Research Centre)

  • Myaing M. Nyunt

    (Duke Global Health Institute, Duke University)

  • Joana C. Silva

    (University of Maryland School of Medicine
    University of Maryland School of Medicine)

  • Kathleen E. Stewart

    (University of Oxford)

  • Christopher V. Plowe

    (Duke Global Health Institute, Duke University)

  • Timothy D. O’Connor

    (University of Maryland School of Medicine
    University of Maryland School of Medicine)

  • Shannon Takala-Harrison

    (University of Maryland School of Medicine)

Abstract

Estimates of Plasmodium falciparum migration may inform strategies for malaria elimination. Here we elucidate fine-scale parasite population structure and infer recent migration across Southeast Asia using identity-by-descent (IBD) approaches based on genome-wide single nucleotide polymorphisms called in 1722 samples from 54 districts. IBD estimates are consistent with isolation-by-distance. We observe greater sharing of larger IBD segments between artemisinin-resistant parasites versus sensitive parasites, which is consistent with the recent spread of drug resistance. Our IBD analyses reveal actionable patterns, including isolated parasite populations, which may be prioritized for malaria elimination, as well as asymmetrical migration identifying potential sources and sinks of migrating parasites.

Suggested Citation

  • Amol C. Shetty & Christopher G. Jacob & Fang Huang & Yao Li & Sonia Agrawal & David L. Saunders & Chanthap Lon & Mark M. Fukuda & Pascal Ringwald & Elizabeth A. Ashley & Kay Thwe Han & Tin Maung Hlain, 2019. "Genomic structure and diversity of Plasmodium falciparum in Southeast Asia reveal recent parasite migration patterns," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10121-3
    DOI: 10.1038/s41467-019-10121-3
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-019-10121-3
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-019-10121-3?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Bing Guo & Victor Borda & Roland Laboulaye & Michele D. Spring & Mariusz Wojnarski & Brian A. Vesely & Joana C. Silva & Norman C. Waters & Timothy D. O’Connor & Shannon Takala-Harrison, 2024. "Strong positive selection biases identity-by-descent-based inferences of recent demography and population structure in Plasmodium falciparum," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Aurel Holzschuh & Anita Lerch & Inna Gerlovina & Bakar S. Fakih & Abdul-wahid H. Al-mafazy & Erik J. Reaves & Abdullah Ali & Faiza Abbas & Mohamed Haji Ali & Mohamed Ali Ali & Manuel W. Hetzel & Joshu, 2023. "Multiplexed ddPCR-amplicon sequencing reveals isolated Plasmodium falciparum populations amenable to local elimination in Zanzibar, Tanzania," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10121-3. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.