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Development of an immunodeficient pig model allowing long-term accommodation of artificial human vascular tubes

Author

Listed:
  • Manabu Itoh

    (Saga University)

  • Yosuke Mukae

    (Saga University)

  • Takahiro Kitsuka

    (Saga University)

  • Kenichi Arai

    (Saga University)

  • Anna Nakamura

    (Saga University)

  • Kazuyoshi Uchihashi

    (National Hospital Organization Saga Hospital)

  • Shuji Toda

    (Saga University)

  • Kumika Matsubayashi

    (Cyfuse Biomedical K. K.)

  • Jun-ichi Oyama

    (Saga University)

  • Koichi Node

    (Saga University)

  • Daisuke Kami

    (Kyoto Prefectural University of Medicine)

  • Satoshi Gojo

    (Kyoto Prefectural University of Medicine)

  • Shigeki Morita

    (National Hospital Organization Kyushu Medical Center)

  • Takahiro Nishida

    (Saga University)

  • Koichi Nakayama

    (Saga University)

  • Eiji Kobayashi

    (Keio University School of Medicine)

Abstract

Before they are used in the clinical setting, the effectiveness of artificially produced human-derived tissue-engineered medical products should be verified in an immunodeficient animal model, such as severe combined immunodeficient mice. However, small animal models are not sufficient to evaluate large-sized products for human use. Thus, an immunodeficient large animal model is necessary in order to properly evaluate the clinical efficacy of human-derived tissue-engineered products, such as artificial grafts. Here we report the development of an immunodeficient pig model, the operational immunodeficient pig (OIDP), by surgically removing the thymus and spleen, and creating a controlled immunosuppressive protocol using a combination of drugs commonly used in the clinical setting. We find that this model allows the long-term accommodation of artificial human vascular grafts. The development of the OIDP is an essential step towards a comprehensive and clinically relevant evaluation of human cell regeneration strategies at the preclinical stage.

Suggested Citation

  • Manabu Itoh & Yosuke Mukae & Takahiro Kitsuka & Kenichi Arai & Anna Nakamura & Kazuyoshi Uchihashi & Shuji Toda & Kumika Matsubayashi & Jun-ichi Oyama & Koichi Node & Daisuke Kami & Satoshi Gojo & Shi, 2019. "Development of an immunodeficient pig model allowing long-term accommodation of artificial human vascular tubes," Nature Communications, Nature, vol. 10(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10107-1
    DOI: 10.1038/s41467-019-10107-1
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