Author
Listed:
- Kim-Long Truong
(Institute of Medical Immunology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health)
- Stephan Schlickeiser
(Institute of Medical Immunology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
Charité – Universitätsmedizin Berlin)
- Katrin Vogt
(Institute of Medical Immunology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health)
- David Boës
(Institute of Medical Immunology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health)
- Katarina Stanko
(Institute of Medical Immunology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health)
- Christine Appelt
(Institute of Medical Immunology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health)
- Mathias Streitz
(Institute of Medical Immunology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health)
- Gerald Grütz
(Institute of Medical Immunology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
Charité – Universitätsmedizin Berlin)
- Nadja Stobutzki
(Institute of Medical Immunology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health)
- Christian Meisel
(Institute of Medical Immunology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health)
- Christina Iwert
(Institute of Medical Immunology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health)
- Stefan Tomiuk
(Milteny Biotec GmbH)
- Julia K. Polansky
(Charité – Universitätsmedizin Berlin
German Rheumatism Research Centre)
- Andreas Pascher
(Charité – Universitätsmedizin Berlin)
- Nina Babel
(Charité – Universitätsmedizin Berlin
University Clinic of Ruhr-University Bochum)
- Ulrik Stervbo
(University Clinic of Ruhr-University Bochum)
- Igor Sauer
(Charité – Universitätsmedizin Berlin)
- Undine Gerlach
(Charité – Universitätsmedizin Berlin)
- Birgit Sawitzki
(Institute of Medical Immunology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
Charité – Universitätsmedizin Berlin)
Abstract
All memory T cells mount an accelerated response on antigen reencounter, but significant functional heterogeneity is present within the respective memory T-cell subsets as defined by CCR7 and CD45RA expression, thereby warranting further stratification. Here we show that several surface markers, including KLRB1, KLRG1, GPR56, and KLRF1, help define low, high, or exhausted cytokine producers within human peripheral and intrahepatic CD4+ memory T-cell populations. Highest simultaneous production of TNF and IFN-γ is observed in KLRB1+KLRG1+GPR56+ CD4 T cells. By contrast, KLRF1 expression is associated with T-cell exhaustion and reduced TNF/IFN-γ production. Lastly, TCRβ repertoire analysis and in vitro differentiation support a regulated, progressive expression for these markers during CD4+ memory T-cell differentiation. Our results thus help refine the classification of human memory T cells to provide insights on inflammatory disease progression and immunotherapy development.
Suggested Citation
Kim-Long Truong & Stephan Schlickeiser & Katrin Vogt & David Boës & Katarina Stanko & Christine Appelt & Mathias Streitz & Gerald Grütz & Nadja Stobutzki & Christian Meisel & Christina Iwert & Stefan , 2019.
"Killer-like receptors and GPR56 progressive expression defines cytokine production of human CD4+ memory T cells,"
Nature Communications, Nature, vol. 10(1), pages 1-15, December.
Handle:
RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10018-1
DOI: 10.1038/s41467-019-10018-1
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