IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v10y2019i1d10.1038_s41467-019-09969-2.html
   My bibliography  Save this article

Skin immunisation activates an innate lymphoid cell-monocyte axis regulating CD8+ effector recruitment to mucosal tissues

Author

Listed:
  • Marija Zaric

    (King’s College London)

  • Pablo D. Becker

    (King’s College London)

  • Catherine Hervouet

    (King’s College London)

  • Petya Kalcheva

    (King’s College London)

  • Andor Doszpoly

    (University of Edinburgh)

  • Negin Blattman

    (Arizona State University)

  • Lauren A. O’ Neill

    (King’s College London)

  • Barbara Ibarzo Yus

    (King’s College London)

  • Clement Cocita

    (King’s College London)

  • Sung-Yun Kwon

    (TheraJect Inc)

  • Andrew H. Baker

    (University of Edinburgh)

  • Graham M. Lord

    (King’s College London
    University of Manchester)

  • Linda S. Klavinskis

    (King’s College London)

Abstract

CD8+ T cells provide a critical defence from pathogens at mucosal epithelia including the female reproductive tract (FRT). Mucosal immunisation is considered essential to initiate this response, however this is difficult to reconcile with evidence that antigen delivered to skin can recruit protective CD8+ T cells to mucosal tissues. Here we dissect the underlying mechanism. We show that adenovirus serotype 5 (Ad5) bio-distributes at very low level to non-lymphoid tissues after skin immunisation. This drives the expansion and activation of CD3− NK1.1+ group 1 innate lymphoid cells (ILC1) within the FRT, essential for recruitment of CD8+ T-cell effectors. Interferon gamma produced by activated ILC1 is critical to licence CD11b+Ly6C+ monocyte production of CXCL9, a chemokine required to recruit skin primed CXCR3+ CD8+T-cells to the FRT. Our findings reveal a novel role for ILC1 to recruit effector CD8+ T-cells to prevent virus spread and establish immune surveillance at barrier tissues.

Suggested Citation

  • Marija Zaric & Pablo D. Becker & Catherine Hervouet & Petya Kalcheva & Andor Doszpoly & Negin Blattman & Lauren A. O’ Neill & Barbara Ibarzo Yus & Clement Cocita & Sung-Yun Kwon & Andrew H. Baker & Gr, 2019. "Skin immunisation activates an innate lymphoid cell-monocyte axis regulating CD8+ effector recruitment to mucosal tissues," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09969-2
    DOI: 10.1038/s41467-019-09969-2
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-019-09969-2
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-019-09969-2?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09969-2. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.