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Small intestinal microbial dysbiosis underlies symptoms associated with functional gastrointestinal disorders

Author

Listed:
  • George B. Saffouri

    (Mayo Clinic)

  • Robin R. Shields-Cutler

    (University of Minnesota
    Macalester College)

  • Jun Chen

    (Mayo Clinic)

  • Yi Yang

    (Imperial College)

  • Heather R. Lekatz

    (Mayo Clinic)

  • Vanessa L. Hale

    (The Ohio State University)

  • Janice M. Cho

    (Mayo Clinic)

  • Eric J. Battaglioli

    (Mayo Clinic)

  • Yogesh Bhattarai

    (Mayo Clinic)

  • Kevin J. Thompson

    (Mayo Clinic)

  • Krishna K. Kalari

    (Mayo Clinic)

  • Gaurav Behera

    (Mayo Clinic)

  • Jonathan C. Berry

    (Mayo Clinic)

  • Stephanie A. Peters

    (Mayo Clinic)

  • Robin Patel

    (Mayo Clinic)

  • Audrey N. Schuetz

    (Mayo Clinic)

  • Jeremiah J. Faith

    (Icahn School of Medicine at Mount Sinai)

  • Michael Camilleri

    (Mayo Clinic
    Mayo Clinic)

  • Justin L. Sonnenburg

    (Stanford University)

  • Gianrico Farrugia

    (Mayo Clinic)

  • Jonathan R. Swann

    (Imperial College)

  • Madhusudan Grover

    (Mayo Clinic
    Mayo Clinic)

  • Dan Knights

    (University of Minnesota
    University of Minnesota)

  • Purna C. Kashyap

    (Mayo Clinic
    Mayo Clinic)

Abstract

Small intestinal bacterial overgrowth (SIBO) has been implicated in symptoms associated with functional gastrointestinal disorders (FGIDs), though mechanisms remain poorly defined and treatment involves non-specific antibiotics. Here we show that SIBO based on duodenal aspirate culture reflects an overgrowth of anaerobes, does not correspond with patient symptoms, and may be a result of dietary preferences. Small intestinal microbial composition, on the other hand, is significantly altered in symptomatic patients and does not correspond with aspirate culture results. In a pilot interventional study we found that switching from a high fiber diet to a low fiber, high simple sugar diet triggered FGID-related symptoms and decreased small intestinal microbial diversity while increasing small intestinal permeability. Our findings demonstrate that characterizing small intestinal microbiomes in patients with gastrointestinal symptoms may allow a more targeted antibacterial or a diet-based approach to treatment.

Suggested Citation

  • George B. Saffouri & Robin R. Shields-Cutler & Jun Chen & Yi Yang & Heather R. Lekatz & Vanessa L. Hale & Janice M. Cho & Eric J. Battaglioli & Yogesh Bhattarai & Kevin J. Thompson & Krishna K. Kalari, 2019. "Small intestinal microbial dysbiosis underlies symptoms associated with functional gastrointestinal disorders," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09964-7
    DOI: 10.1038/s41467-019-09964-7
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