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A high-throughput screen indicates gemcitabine and JAK inhibitors may be useful for treating pediatric AML

Author

Listed:
  • Christina D. Drenberg

    (The Ohio State University
    The Ohio State University)

  • Anang Shelat

    (St. Jude Children’s Research Hospital)

  • Jinjun Dang

    (St. Jude Children’s Research Hospital)

  • Anitria Cotton

    (St. Jude Children’s Research Hospital)

  • Shelley J. Orwick

    (The Ohio State University)

  • Mengyu Li

    (The Ohio State University
    The Ohio State University)

  • Jae Yoon Jeon

    (The Ohio State University
    The Ohio State University)

  • Qiang Fu

    (The Ohio State University
    The Ohio State University)

  • Daelynn R. Buelow

    (The Ohio State University
    The Ohio State University)

  • Marissa Pioso

    (The Ohio State University
    The Ohio State University)

  • Shuiying Hu

    (The Ohio State University
    The Ohio State University)

  • Hiroto Inaba

    (St. Jude Children’s Research Hospital)

  • Raul C. Ribeiro

    (St. Jude Children’s Research Hospital)

  • Jeffrey E. Rubnitz

    (St. Jude Children’s Research Hospital)

  • Tanja A. Gruber

    (St. Jude Children’s Research Hospital)

  • R. Kiplin Guy

    (University of Kentucky)

  • Sharyn D. Baker

    (The Ohio State University
    The Ohio State University)

Abstract

Improvement in survival has been achieved for children and adolescents with AML but is largely attributed to enhanced supportive care as opposed to the development of better treatment regimens. High risk subtypes continue to have poor outcomes with event free survival rates

Suggested Citation

  • Christina D. Drenberg & Anang Shelat & Jinjun Dang & Anitria Cotton & Shelley J. Orwick & Mengyu Li & Jae Yoon Jeon & Qiang Fu & Daelynn R. Buelow & Marissa Pioso & Shuiying Hu & Hiroto Inaba & Raul C, 2019. "A high-throughput screen indicates gemcitabine and JAK inhibitors may be useful for treating pediatric AML," Nature Communications, Nature, vol. 10(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09917-0
    DOI: 10.1038/s41467-019-09917-0
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    Cited by:

    1. Elizabeth A. R. Garfinkle & Pratima Nallagatla & Binay Sahoo & Jinjun Dang & Mohammad Balood & Anitria Cotton & Camryn Franke & Sharnise Mitchell & Taylor Wilson & Tanja A. Gruber, 2024. "CBFA2T3-GLIS2 mediates transcriptional regulation of developmental pathways through a gene regulatory network," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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