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Regeneration of severely damaged lungs using an interventional cross-circulation platform

Author

Listed:
  • Brandon A. Guenthart

    (Columbia University
    Columbia University)

  • John D. O’Neill

    (Columbia University)

  • Jinho Kim

    (Columbia University
    Stevens Institute of Technology)

  • Dawn Queen

    (Columbia University)

  • Scott Chicotka

    (Columbia University)

  • Kenmond Fung

    (Columbia University)

  • Michael Simpson

    (Columbia University)

  • Rachel Donocoff

    (Columbia University)

  • Michael Salna

    (Columbia University)

  • Charles C. Marboe

    (Columbia University)

  • Katherine Cunningham

    (Columbia University)

  • Susan P. Halligan

    (Columbia University)

  • Holly M. Wobma

    (Columbia University)

  • Ahmed E. Hozain

    (Columbia University
    Columbia University)

  • Alexander Romanov

    (Columbia University)

  • Gordana Vunjak-Novakovic

    (Columbia University
    Columbia University)

  • Matthew Bacchetta

    (Columbia University
    Vanderbilt University)

Abstract

The number of available donor organs limits lung transplantation, the only lifesaving therapy for the increasing population of patients with end-stage lung disease. A prevalent etiology of injury that renders lungs unacceptable for transplantation is gastric aspiration, a deleterious insult to the pulmonary epithelium. Currently, severely damaged donor lungs cannot be salvaged with existing devices or methods. Here we report the regeneration of severely damaged lungs repaired to meet transplantation criteria by utilizing an interventional cross-circulation platform in a clinically relevant swine model of gastric aspiration injury. Enabled by cross-circulation with a living swine, prolonged extracorporeal support of damaged lungs results in significant improvements in lung function, cellular regeneration, and the development of diagnostic tools for non-invasive organ evaluation and repair. We therefore propose that the use of an interventional cross-circulation platform could enable recovery of otherwise unsalvageable lungs and thus expand the donor organ pool.

Suggested Citation

  • Brandon A. Guenthart & John D. O’Neill & Jinho Kim & Dawn Queen & Scott Chicotka & Kenmond Fung & Michael Simpson & Rachel Donocoff & Michael Salna & Charles C. Marboe & Katherine Cunningham & Susan P, 2019. "Regeneration of severely damaged lungs using an interventional cross-circulation platform," Nature Communications, Nature, vol. 10(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09908-1
    DOI: 10.1038/s41467-019-09908-1
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