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Liver-target nanotechnology facilitates berberine to ameliorate cardio-metabolic diseases

Author

Listed:
  • Hui-Hui Guo

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Chen-Lin Feng

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Wen-Xuan Zhang

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Zhi-Gang Luo

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Hong-Juan Zhang

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Ting-Ting Zhang

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Chen Ma

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Yun Zhan

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Rui Li

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Song Wu

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Zeper Abliz

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Cong Li

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Xiao-Lin Li

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Xiao-Lei Ma

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Lu-Lu Wang

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Wen-Sheng Zheng

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Yan-Xing Han

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Jian-Dong Jiang

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

Abstract

Cardiovascular and metabolic disease (CMD) remains a main cause of premature death worldwide. Berberine (BBR), a lipid-lowering botanic compound with diversified potency against metabolic disorders, is a promising candidate for ameliorating CMD. The liver is the target of BBR so that liver-site accumulation could be important for fulfilling its therapeutic effect. In this study a rational designed micelle (CTA-Mic) consisting of α-tocopheryl hydrophobic core and on-site detachable polyethylene glycol-thiol shell is developed for effective liver deposition of BBR. The bio-distribution analysis proves that the accumulation of BBR in liver is increased by 248.8% assisted by micelles. Up-regulation of a range of energy-related genes is detectable in the HepG2 cells and in vivo. In the high fat diet-fed mice, BBR-CTA-Mic intervention remarkably improves metabolic profiles and reduces the formation of aortic arch plaque. Our results provide proof-of-concept for a liver-targeting strategy to ameliorate CMD using natural medicines facilitated by Nano-technology.

Suggested Citation

  • Hui-Hui Guo & Chen-Lin Feng & Wen-Xuan Zhang & Zhi-Gang Luo & Hong-Juan Zhang & Ting-Ting Zhang & Chen Ma & Yun Zhan & Rui Li & Song Wu & Zeper Abliz & Cong Li & Xiao-Lin Li & Xiao-Lei Ma & Lu-Lu Wang, 2019. "Liver-target nanotechnology facilitates berberine to ameliorate cardio-metabolic diseases," Nature Communications, Nature, vol. 10(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09852-0
    DOI: 10.1038/s41467-019-09852-0
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