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Synthetic biology strategies for microbial biosynthesis of plant natural products

Author

Listed:
  • Aaron Cravens

    (Stanford University)

  • James Payne

    (Stanford University)

  • Christina D. Smolke

    (Stanford University
    Chan Zuckerberg Biohub)

Abstract

Metabolic engineers endeavor to create a bio-based manufacturing industry using microbes to produce fuels, chemicals, and medicines. Plant natural products (PNPs) are historically challenging to produce and are ubiquitous in medicines, flavors, and fragrances. Engineering PNP pathways into new hosts requires finding or modifying a suitable host to accommodate the pathway, planning and implementing a biosynthetic route to the compound, and discovering or engineering enzymes for missing steps. In this review, we describe recent developments in metabolic engineering at the level of host, pathway, and enzyme, and discuss how the field is approaching ever more complex biosynthetic opportunities.

Suggested Citation

  • Aaron Cravens & James Payne & Christina D. Smolke, 2019. "Synthetic biology strategies for microbial biosynthesis of plant natural products," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09848-w
    DOI: 10.1038/s41467-019-09848-w
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    Cited by:

    1. Simon d’Oelsnitz & Daniel J. Diaz & Wantae Kim & Daniel J. Acosta & Tyler L. Dangerfield & Mason W. Schechter & Matthew B. Minus & James R. Howard & Hannah Do & James M. Loy & Hal S. Alper & Y. Jessie, 2024. "Biosensor and machine learning-aided engineering of an amaryllidaceae enzyme," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Yuanwei Gou & Dongfang Li & Minghui Zhao & Mengxin Li & Jiaojiao Zhang & Yilian Zhou & Feng Xiao & Gaofei Liu & Haote Ding & Chenfan Sun & Cuifang Ye & Chang Dong & Jucan Gao & Di Gao & Zehua Bao & Le, 2024. "Intein-mediated temperature control for complete biosynthesis of sanguinarine and its halogenated derivatives in yeast," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Wenlong Zha & Fan Zhang & Jiaqi Shao & Xingmei Ma & Jianxun Zhu & Pinghua Sun & Ruibo Wu & Jiachen Zi, 2022. "Rationally engineering santalene synthase to readjust the component ratio of sandalwood oil," Nature Communications, Nature, vol. 13(1), pages 1-10, December.

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