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Spatial and temporal localization of immune transcripts defines hallmarks and diversity in the tuberculosis granuloma

Author

Listed:
  • Berit Carow

    (Karolinska Institutet)

  • Thomas Hauling

    (Stockholm University)

  • Xiaoyan Qian

    (Stockholm University)

  • Igor Kramnik

    (Boston University School of Medicine)

  • Mats Nilsson

    (Stockholm University)

  • Martin E. Rottenberg

    (Karolinska Institutet)

Abstract

Granulomas are the pathological hallmark of tuberculosis (TB) and the niche where bacilli can grow and disseminate or the immunological microenvironment in which host cells interact to prevent bacterial dissemination. Here we show 34 immune transcripts align to the morphology of lung sections from Mycobacterium tuberculosis-infected mice at cellular resolution. Colocalizing transcript networks at

Suggested Citation

  • Berit Carow & Thomas Hauling & Xiaoyan Qian & Igor Kramnik & Mats Nilsson & Martin E. Rottenberg, 2019. "Spatial and temporal localization of immune transcripts defines hallmarks and diversity in the tuberculosis granuloma," Nature Communications, Nature, vol. 10(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09816-4
    DOI: 10.1038/s41467-019-09816-4
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    Cited by:

    1. Juan F. Quintana & Praveena Chandrasegaran & Matthew C. Sinton & Emma M. Briggs & Thomas D. Otto & Rhiannon Heslop & Calum Bentley-Abbot & Colin Loney & Luis de Lecea & Neil A. Mabbott & Annette MacLe, 2022. "Single cell and spatial transcriptomic analyses reveal microglia-plasma cell crosstalk in the brain during Trypanosoma brucei infection," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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