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Anatomical and functional investigation of the marmoset default mode network

Author

Listed:
  • Cirong Liu

    (National Institutes of Health)

  • Cecil Chern-Chyi Yen

    (National Institutes of Health)

  • Diego Szczupak

    (National Institutes of Health)

  • Frank Q. Ye

    (National Institutes of Health)

  • David A. Leopold

    (National Institutes of Health
    National Institutes of Health)

  • Afonso C. Silva

    (National Institutes of Health)

Abstract

The default mode network (DMN) is associated with a wide range of brain functions. In humans, the DMN is marked by strong functional connectivity among three core regions: medial prefrontal cortex (mPFC), posterior parietal cortex (PPC), and the medial parietal and posterior cingulate cortex (PCC). Neuroimaging studies have shown that the DMN also exists in non-human primates, suggesting that it may be a conserved feature of the primate brain. Here, we found that, in common marmosets, the dorsolateral prefrontal cortex (dlPFC; peak at A8aD) has robust fMRI functional connectivity and reciprocal anatomical connections with the posterior DMN core regions (PPC and PCC), while the mPFC has weak connections with the posterior DMN core regions. This strong dlPFC but weak mPFC connectivity in marmoset differs markedly from the stereotypical DMN in humans. The mPFC may be involved in brain functions that are further developed in humans than in other primates.

Suggested Citation

  • Cirong Liu & Cecil Chern-Chyi Yen & Diego Szczupak & Frank Q. Ye & David A. Leopold & Afonso C. Silva, 2019. "Anatomical and functional investigation of the marmoset default mode network," Nature Communications, Nature, vol. 10(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09813-7
    DOI: 10.1038/s41467-019-09813-7
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    Cited by:

    1. Kyle M. Gilbert & Justine C. Cléry & Joseph S. Gati & Yuki Hori & Kevin D. Johnston & Alexander Mashkovtsev & Janahan Selvanayagam & Peter Zeman & Ravi S. Menon & David J. Schaeffer & Stefan Everling, 2021. "Simultaneous functional MRI of two awake marmosets," Nature Communications, Nature, vol. 12(1), pages 1-11, December.

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