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YAP-independent mechanotransduction drives breast cancer progression

Author

Listed:
  • Joanna Y. Lee

    (Stanford University)

  • Jessica K. Chang

    (Department of Genetics, Stanford University School of Medicine)

  • Antonia A. Dominguez

    (Stanford University
    Stanford University
    Stanford University)

  • Hong-pyo Lee

    (Stanford University)

  • Sungmin Nam

    (Stanford University)

  • Julie Chang

    (Stanford University)

  • Sushama Varma

    (Stanford University School of Medicine)

  • Lei S. Qi

    (Stanford University
    Stanford University)

  • Robert B. West

    (Stanford University School of Medicine)

  • Ovijit Chaudhuri

    (Stanford University)

Abstract

Increased tissue stiffness is a driver of breast cancer progression. The transcriptional regulator YAP is considered a universal mechanotransducer, based largely on 2D culture studies. However, the role of YAP during in vivo breast cancer remains unclear. Here, we find that mechanotransduction occurs independently of YAP in breast cancer patient samples and mechanically tunable 3D cultures. Mechanistically, the lack of YAP activity in 3D culture and in vivo is associated with the absence of stress fibers and an order of magnitude decrease in nuclear cross-sectional area relative to 2D culture. This work highlights the context-dependent role of YAP in mechanotransduction, and establishes that YAP does not mediate mechanotransduction in breast cancer.

Suggested Citation

  • Joanna Y. Lee & Jessica K. Chang & Antonia A. Dominguez & Hong-pyo Lee & Sungmin Nam & Julie Chang & Sushama Varma & Lei S. Qi & Robert B. West & Ovijit Chaudhuri, 2019. "YAP-independent mechanotransduction drives breast cancer progression," Nature Communications, Nature, vol. 10(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09755-0
    DOI: 10.1038/s41467-019-09755-0
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