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PDGFRα+ stromal adipocyte progenitors transition into epithelial cells during lobulo-alveologenesis in the murine mammary gland

Author

Listed:
  • Purna A. Joshi

    (Princess Margaret Cancer Centre)

  • Paul D. Waterhouse

    (Princess Margaret Cancer Centre)

  • Katayoon Kasaian

    (Ontario Institute for Cancer Research)

  • Hui Fang

    (Princess Margaret Cancer Centre)

  • Olga Gulyaeva

    (University of California)

  • Hei Sook Sul

    (University of California
    University of California)

  • Paul C. Boutros

    (Ontario Institute for Cancer Research
    University of Toronto)

  • Rama Khokha

    (Princess Margaret Cancer Centre
    University of Toronto)

Abstract

The mammary gland experiences substantial remodeling and regeneration during development and reproductive life, facilitated by stem cells and progenitors that act in concert with physiological stimuli. While studies have focused on deciphering regenerative cells within the parenchymal epithelium, cell lineages in the stroma that may directly contribute to epithelial biology is unknown. Here we identify, in mouse, the transition of a PDGFRα+ mesenchymal cell population into mammary epithelial progenitors. In addition to being adipocyte progenitors, PDGFRα+ cells make a de novo contribution to luminal and basal epithelia during mammary morphogenesis. In the adult, this mesenchymal lineage primarily generates luminal progenitors within lobuloalveoli during sex hormone exposure or pregnancy. We identify cell migration as a key molecular event that is activated in mesenchymal progenitors in response to epithelium-derived chemoattractant. These findings demonstrate a stromal reservoir of epithelial progenitors and provide insight into cell origins and plasticity during mammary tissue growth.

Suggested Citation

  • Purna A. Joshi & Paul D. Waterhouse & Katayoon Kasaian & Hui Fang & Olga Gulyaeva & Hei Sook Sul & Paul C. Boutros & Rama Khokha, 2019. "PDGFRα+ stromal adipocyte progenitors transition into epithelial cells during lobulo-alveologenesis in the murine mammary gland," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09748-z
    DOI: 10.1038/s41467-019-09748-z
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