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Scalable dissolution-dynamic nuclear polarization with rapid transfer of a polarized solid

Author

Listed:
  • Karel Kouřil

    (University of Southampton)

  • Hana Kouřilová

    (University of Southampton)

  • Samuel Bartram

    (University of Southampton)

  • Malcolm H. Levitt

    (University of Southampton)

  • Benno Meier

    (University of Southampton)

Abstract

In dissolution-dynamic nuclear polarization, nuclear spins are hyperpolarized at cryogenic temperatures using radicals and microwave irradiation. The hyperpolarized solid is dissolved with hot solvent and the solution is transferred to a secondary magnet where strongly enhanced magnetic resonance signals are observed. Here we present a method for transferring the hyperpolarized solid. A bullet containing the frozen, hyperpolarized sample is ejected using pressurized helium gas, and shot into a receiving structure in the secondary magnet, where the bullet is retained and the polarized solid is dissolved rapidly. The transfer takes approximately 70 ms. A solenoid, wound along the entire transfer path ensures adiabatic transfer and limits radical-induced low-field relaxation. The method is fast and scalable towards small volumes suitable for high-resolution nuclear magnetic resonance spectroscopy while maintaining high concentrations of the target molecule. Polarization levels of approximately 30% have been observed for 1-13C-labelled pyruvic acid in solution.

Suggested Citation

  • Karel Kouřil & Hana Kouřilová & Samuel Bartram & Malcolm H. Levitt & Benno Meier, 2019. "Scalable dissolution-dynamic nuclear polarization with rapid transfer of a polarized solid," Nature Communications, Nature, vol. 10(1), pages 1-6, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09726-5
    DOI: 10.1038/s41467-019-09726-5
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    Cited by:

    1. Nergiz Sahin Solmaz & Reza Farsi & Giovanni Boero, 2024. "200 GHz single chip microsystems for dynamic nuclear polarization enhanced NMR spectroscopy," Nature Communications, Nature, vol. 15(1), pages 1-10, December.

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