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Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

Author

Listed:
  • Leanne K. Küpers

    (University of Bristol
    University of Bristol
    University Medical Center Groningen, Department of Epidemiology
    Wageningen University)

  • Claire Monnereau

    (University Medical Center Rotterdam
    University Medical Center Rotterdam
    University Medical Center Rotterdam)

  • Gemma C. Sharp

    (University of Bristol
    University of Bristol)

  • Paul Yousefi

    (University of Bristol
    University of Bristol
    University of California)

  • Lucas A. Salas

    (Geisel School of Medicine at Dartmouth College
    ISGlobal, Bacelona Institute for Global Health)

  • Akram Ghantous

    (Epigenetics Group, International Agency for Research on Cancer)

  • Christian M. Page

    (Norwegian Institute of Public Health
    Oslo University Hospital)

  • Sarah E. Reese

    (Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Service, Research Triangle Park)

  • Allen J. Wilcox

    (Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Service, Research Triangle Park)

  • Darina Czamara

    (Max-Planck-Institute of Psychiatry)

  • Anne P. Starling

    (University of Colorado Anschutz Medical Campus)

  • Alexei Novoloaca

    (Epigenetics Group, International Agency for Research on Cancer)

  • Samantha Lent

    (Boston University School of Public Health)

  • Ritu Roy

    (University of California
    Computational Biology and Informatics, UCSF)

  • Cathrine Hoyo

    (North Carolina State University
    North Carolina State University)

  • Carrie V. Breton

    (University of Southern California)

  • Catherine Allard

    (Centre de recherche du Centre hospitalier universitaire de Sherbrooke)

  • Allan C. Just

    (Icahn School of Medicine at Mount Sinai)

  • Kelly M. Bakulski

    (University of Michigan)

  • John W. Holloway

    (University of Southampton
    University of Southampton, Southampton General Hospital)

  • Todd M. Everson

    (Rollins School of Public Health at Emory University)

  • Cheng-Jian Xu

    (University Medical Center Groningen, Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children’s Hospital, Groningen Research Institute for Asthma and COPD
    University Medical Center Groningen, Department of Genetics)

  • Rae-Chi Huang

    (University of Western Australia)

  • Diana A. van der Plaat

    (University Medical Center Groningen, Department of Epidemiology and Groningen Research Institute for Asthma and COPD (GRIAC))

  • Matthias Wielscher

    (School of Public Health, Imperial College London)

  • Simon Kebede Merid

    (Institute of Environmental Medicine, Karolinska Institutet)

  • Vilhelmina Ullemar

    (Karolinska Institutet)

  • Faisal I. Rezwan

    (University of Southampton, Southampton General Hospital)

  • Jari Lahti

    (University of Helsinki
    University of Helsinki)

  • Jenny van Dongen

    (Vrije Universiteit Amsterdam)

  • Sabine A. S. Langie

    (VITO - Health
    Hasselt University
    Hasselt University)

  • Tom G. Richardson

    (University of Bristol
    University of Bristol)

  • Maria C. Magnus

    (University of Bristol
    University of Bristol
    Norwegian Institute of Public Health)

  • Ellen A. Nohr

    (University of Southern Denmark)

  • Zongli Xu

    (University Medical Center Rotterdam)

  • Liesbeth Duijts

    (Wageningen University
    University Medical Center Rotterdam
    University Medical Center Rotterdam)

  • Shanshan Zhao

    (National Institute of Environmental Health Sciences, NIH, Research Triangle Park)

  • Weiming Zhang

    (University of Colorado Anschutz Medical Campus)

  • Michelle Plusquin

    (Hasselt University
    MRC/PHE Centre for Environment and Health School of Public Health Imperial College London, St Mary’s Campus, Norfolk Place)

  • Dawn L. DeMeo

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Olivia Solomon

    (University of Bristol)

  • Joosje H. Heimovaara

    (University Medical Center Groningen, Department of Epidemiology)

  • Dereje D. Jima

    (North Carolina State University
    North Carolina State University)

  • Lu Gao

    (University of Southern California)

  • Mariona Bustamante

    (ISGlobal, Bacelona Institute for Global Health
    Bioinformatics and Genomics Program, Centre for Genomic Regulation (CRG)
    Universitat Pompeu Fabra (UPF)
    CIBER Epidemiología y Salud Pública (CIBERESP))

  • Patrice Perron

    (Centre de recherche du Centre hospitalier universitaire de Sherbrooke
    Universite de Sherbrooke)

  • Robert O. Wright

    (Icahn School of Medicine at Mount Sinai)

  • Irva Hertz-Picciotto

    (University of California Davis MIND Institute)

  • Hongmei Zhang

    (University of Memphis)

  • Margaret R. Karagas

    (Geisel School of Medicine at Dartmouth College
    Children’s Environmental Health & Disease Prevention Research Center at Dartmouth)

  • Ulrike Gehring

    (Utrecht University)

  • Carmen J. Marsit

    (Rollins School of Public Health at Emory University)

  • Lawrence J. Beilin

    (University of Western Australia)

  • Judith M. Vonk

    (University Medical Center Groningen, Department of Epidemiology and Groningen Research Institute for Asthma and COPD (GRIAC))

  • Marjo-Riitta Jarvelin

    (School of Public Health, Imperial College London
    University of Oulu
    University of Oulu
    Oulu University Hospital)

  • Anna Bergström

    (Institute of Environmental Medicine, Karolinska Institutet
    Stockholm County Council)

  • Anne K. Örtqvist

    (Karolinska Institutet)

  • Susan Ewart

    (Michigan State University)

  • Pia M. Villa

    (University of Helsinki and Helsinki University Hospital)

  • Sophie E. Moore

    (Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine
    King’s College London)

  • Gonneke Willemsen

    (Vrije Universiteit Amsterdam)

  • Arnout R. L. Standaert

    (VITO - Health)

  • Siri E. Håberg

    (Norwegian Institute of Public Health)

  • Thorkild I. A. Sørensen

    (University of Bristol
    University of Copenhagen
    University of Copenhagen)

  • Jack A. Taylor

    (Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Service, Research Triangle Park)

  • Katri Räikkönen

    (University of Helsinki)

  • Ivana V. Yang

    (University of Colorado Anschutz Medical Campus)

  • Katerina Kechris

    (University Medical Center Rotterdam)

  • Tim S. Nawrot

    (Hasselt University
    Leuven University)

  • Matt J. Silver

    (Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine)

  • Yun Yun Gong

    (University of Leeds)

  • Lorenzo Richiardi

    (University of Turin
    AOU Citta della Salute e della Sceinza, CPO Piemonte)

  • Manolis Kogevinas

    (ISGlobal, Bacelona Institute for Global Health
    Universitat Pompeu Fabra (UPF)
    CIBER Epidemiología y Salud Pública (CIBERESP)
    IMIM (Hospital del Mar Medical Research Institute))

  • Augusto A. Litonjua

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Brenda Eskenazi

    (University of California
    University of California)

  • Karen Huen

    (University of California)

  • Hamdi Mbarek

    (Vrije Universiteit Amsterdam)

  • Rachel L. Maguire

    (North Carolina State University
    Duke University Medical Center)

  • Terence Dwyer

    (University of Oxford)

  • Martine Vrijheid

    (ISGlobal, Bacelona Institute for Global Health
    Universitat Pompeu Fabra (UPF)
    CIBER Epidemiología y Salud Pública (CIBERESP))

  • Luigi Bouchard

    (Université de Sherbrooke
    Chicoutimi Hospital)

  • Andrea A. Baccarelli

    (Columbia University Mailman School of Public Health
    Columbia University)

  • Lisa A. Croen

    (Division of Research, Kaiser Permanente Northern California)

  • Wilfried Karmaus

    (University of Memphis)

  • Denise Anderson

    (University of Western Australia)

  • Maaike de Vries

    (University Medical Center Groningen, Department of Epidemiology and Groningen Research Institute for Asthma and COPD (GRIAC))

  • Sylvain Sebert

    (University of Oulu
    University of Oulu
    School of Public Health, Imperial College London)

  • Juha Kere

    (University of Helsinki
    Karolinska Institutet
    King’s College London, Guy’s Hospital)

  • Robert Karlsson

    (Karolinska Institutet)

  • Syed Hasan Arshad

    (University of Southampton
    David Hide Asthma and Allergy Research Centre)

  • Esa Hämäläinen

    (University of Helsinki)

  • Michael N. Routledge

    (LICAMM, School of Medicine, Univeristy of Leeds)

  • Dorret I. Boomsma

    (Vrije Universiteit Amsterdam
    Vrije Universiteit Amsterdam)

  • Andrew P. Feinberg

    (Johns Hopkins University School of Medicine)

  • Craig J. Newschaffer

    (Drexel University)

  • Eva Govarts

    (VITO - Health)

  • Matthieu Moisse

    (KU Leuven – University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Institute for Neuroscience and Disease (LIND)
    VIB, Center for Brain & Disease Research, Laboratory of Neurobiology)

  • M. Daniele Fallin

    (Johns Hopkins University)

  • Erik Melén

    (Institute of Environmental Medicine, Karolinska Institutet
    Sachs’ Children’s Hospital)

  • Andrew M. Prentice

    (Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine)

  • Eero Kajantie

    (National Institute for Health and Welfare, Helsinki and Oulu
    Helsinki University Hospital and University of Helsinki
    Oulu University Hospital and University of Oulu)

  • Catarina Almqvist

    (Karolinska Institutet
    Karolinska University Hospital)

  • Emily Oken

    (Harvard Pilgrim Health Care Institute)

  • Dana Dabelea

    (University of Colorado School of Medicine, University of Colorado Anschutz Medical Campus)

  • H. Marike Boezen

    (University Medical Center Groningen, Department of Epidemiology and Groningen Research Institute for Asthma and COPD (GRIAC))

  • Phillip E. Melton

    (University of Western Australia
    Curtin University)

  • Rosalind J. Wright

    (Icahn School of Medicine at Mount Sinai)

  • Gerard H. Koppelman

    (University Medical Center Groningen, Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children’s Hospital, Groningen Research Institute for Asthma and COPD)

  • Letizia Trevisi

    (Harvard Medical School)

  • Marie-France Hivert

    (Universite de Sherbrooke
    Harvard Pilgrim Health Care Institute
    Diabetes Unit, Massachusetts General Hospital)

  • Jordi Sunyer

    (ISGlobal, Bacelona Institute for Global Health
    Universitat Pompeu Fabra (UPF)
    CIBER Epidemiología y Salud Pública (CIBERESP)
    IMIM (Hospital del Mar Medical Research Institute))

  • Monica C. Munthe-Kaas

    (Norwegian Institute of Public Health
    Oslo University Hospital)

  • Susan K. Murphy

    (Duke University Medical Center)

  • Eva Corpeleijn

    (University Medical Center Groningen, Department of Epidemiology)

  • Joseph Wiemels

    (University of California)

  • Nina Holland

    (University of California)

  • Zdenko Herceg

    (Epigenetics Group, International Agency for Research on Cancer)

  • Elisabeth B. Binder

    (Max-Planck-Institute of Psychiatry
    Emory University School of Medicine)

  • George Davey Smith

    (University of Bristol
    University of Bristol)

  • Vincent W. V. Jaddoe

    (University Medical Center Rotterdam
    University Medical Center Rotterdam
    University Medical Center Rotterdam)

  • Rolv T. Lie

    (Norwegian Institute of Public Health
    University of Bergen)

  • Wenche Nystad

    (Norwegian Institute for Public Health)

  • Stephanie J. London

    (Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Service, Research Triangle Park)

  • Debbie A. Lawlor

    (University of Bristol
    University of Bristol)

  • Caroline L. Relton

    (University of Bristol
    University of Bristol)

  • Harold Snieder

    (University Medical Center Groningen, Department of Epidemiology)

  • Janine F. Felix

    (University Medical Center Rotterdam
    University Medical Center Rotterdam
    University Medical Center Rotterdam)

Abstract

Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from −183 to 178 grams per 10% increase in methylation (PBonferroni

Suggested Citation

  • Leanne K. Küpers & Claire Monnereau & Gemma C. Sharp & Paul Yousefi & Lucas A. Salas & Akram Ghantous & Christian M. Page & Sarah E. Reese & Allen J. Wilcox & Darina Czamara & Anne P. Starling & Alexe, 2019. "Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09671-3
    DOI: 10.1038/s41467-019-09671-3
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