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Intrinsic functional architecture of the non-human primate spinal cord derived from fMRI and electrophysiology

Author

Listed:
  • Tung-Lin Wu

    (Vanderbilt University Institute of Imaging Science
    Biomedical Engineering, Vanderbilt University)

  • Pai-Feng Yang

    (Vanderbilt University Institute of Imaging Science
    Radiology and Radiological Sciences, Vanderbilt University Medical Center)

  • Feng Wang

    (Vanderbilt University Institute of Imaging Science
    Radiology and Radiological Sciences, Vanderbilt University Medical Center)

  • Zhaoyue Shi

    (Vanderbilt University Institute of Imaging Science
    Biomedical Engineering, Vanderbilt University)

  • Arabinda Mishra

    (Vanderbilt University Institute of Imaging Science
    Radiology and Radiological Sciences, Vanderbilt University Medical Center)

  • Ruiqi Wu

    (Vanderbilt University Institute of Imaging Science)

  • Li Min Chen

    (Vanderbilt University Institute of Imaging Science
    Radiology and Radiological Sciences, Vanderbilt University Medical Center)

  • John C. Gore

    (Vanderbilt University Institute of Imaging Science
    Biomedical Engineering, Vanderbilt University
    Radiology and Radiological Sciences, Vanderbilt University Medical Center
    Vanderbilt University)

Abstract

Resting-state functional MRI (rsfMRI) has recently revealed correlated signals in the spinal cord horns of monkeys and humans. However, the interpretation of these rsfMRI correlations as indicators of functional connectivity in the spinal cord remains unclear. Here, we recorded stimulus-evoked and spontaneous spiking activity and local field potentials (LFPs) from monkey spinal cord in order to validate fMRI measures. We found that both BOLD and electrophysiological signals elicited by tactile stimulation co-localized to the ipsilateral dorsal horn. Temporal profiles of stimulus-evoked BOLD signals covaried with LFP and multiunit spiking in a similar way to those observed in the brain. Functional connectivity of dorsal horns exhibited a U-shaped profile along the dorsal-intermediate-ventral axis. Overall, these results suggest that there is an intrinsic functional architecture within the gray matter of a single spinal segment, and that rsfMRI signals at high field directly reflect this underlying spontaneous neuronal activity.

Suggested Citation

  • Tung-Lin Wu & Pai-Feng Yang & Feng Wang & Zhaoyue Shi & Arabinda Mishra & Ruiqi Wu & Li Min Chen & John C. Gore, 2019. "Intrinsic functional architecture of the non-human primate spinal cord derived from fMRI and electrophysiology," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09485-3
    DOI: 10.1038/s41467-019-09485-3
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