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Meta-analysis of genome-wide association studies provides insights into genetic control of tomato flavor

Author

Listed:
  • Jiantao Zhao

    (INRA, UR1052, Génétique et Amélioration des Fruits et Légumes, Domaine Saint Maurice)

  • Christopher Sauvage

    (INRA, UR1052, Génétique et Amélioration des Fruits et Légumes, Domaine Saint Maurice
    Syngenta, 12 Chemin de l’Hobit)

  • Jinghua Zhao

    (University of Cambridge, Addrenbrooke’s Hospital
    University of Cambridge)

  • Frédérique Bitton

    (INRA, UR1052, Génétique et Amélioration des Fruits et Légumes, Domaine Saint Maurice)

  • Guillaume Bauchet

    (INRA, UR1052, Génétique et Amélioration des Fruits et Légumes, Domaine Saint Maurice
    Boyce Thompson Institute, Cornell University)

  • Dan Liu

    (Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences)

  • Sanwen Huang

    (Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences
    Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences)

  • Denise M. Tieman

    (University of Florida)

  • Harry J. Klee

    (University of Florida)

  • Mathilde Causse

    (INRA, UR1052, Génétique et Amélioration des Fruits et Légumes, Domaine Saint Maurice)

Abstract

Tomato flavor has changed over the course of long-term domestication and intensive breeding. To understand the genetic control of flavor, we report the meta-analysis of genome-wide association studies (GWAS) using 775 tomato accessions and 2,316,117 SNPs from three GWAS panels. We discover 305 significant associations for the contents of sugars, acids, amino acids, and flavor-related volatiles. We demonstrate that fruit citrate and malate contents have been impacted by selection during domestication and improvement, while sugar content has undergone less stringent selection. We suggest that it may be possible to significantly increase volatiles that positively contribute to consumer preferences while reducing unpleasant volatiles, by selection of the relevant allele combinations. Our results provide genetic insights into the influence of human selection on tomato flavor and demonstrate the benefits obtained from meta-analysis.

Suggested Citation

  • Jiantao Zhao & Christopher Sauvage & Jinghua Zhao & Frédérique Bitton & Guillaume Bauchet & Dan Liu & Sanwen Huang & Denise M. Tieman & Harry J. Klee & Mathilde Causse, 2019. "Meta-analysis of genome-wide association studies provides insights into genetic control of tomato flavor," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09462-w
    DOI: 10.1038/s41467-019-09462-w
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