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A new type of DNA phosphorothioation-based antiviral system in archaea

Author

Listed:
  • Lei Xiong

    (Wuhan University
    Hubei University of Medicine
    Wuhan University)

  • Siyi Liu

    (Wuhan University
    Wuhan University)

  • Si Chen

    (Wuhan Polytechnic University)

  • Yao Xiao

    (Wuhan University
    Wuhan University)

  • Bochen Zhu

    (Wuhan University
    Wuhan University)

  • Yali Gao

    (Wuhan University
    Wuhan University)

  • Yujing Zhang

    (Wuhan University
    Wuhan University)

  • Beibei Chen

    (Wuhan University)

  • Jie Luo

    (Hubei University of Medicine)

  • Zixin Deng

    (Wuhan University)

  • Xiangdong Chen

    (Wuhan University)

  • Lianrong Wang

    (Wuhan University
    Hubei University of Medicine
    Wuhan University)

  • Shi Chen

    (Wuhan University
    Hubei University of Medicine
    Wuhan University)

Abstract

Archaea and Bacteria have evolved different defence strategies that target virtually all steps of the viral life cycle. The diversified virion morphotypes and genome contents of archaeal viruses result in a highly complex array of archaea-virus interactions. However, our understanding of archaeal antiviral activities lags far behind our knowledges of those in bacteria. Here we report a new archaeal defence system that involves DndCDEA-specific DNA phosphorothioate (PT) modification and the PbeABCD-mediated halt of virus propagation via inhibition of DNA replication. In contrast to the breakage of invasive DNA by DndFGH in bacteria, DndCDEA-PbeABCD does not degrade or cleave viral DNA. The PbeABCD-mediated PT defence system is widespread and exhibits extensive interdomain and intradomain gene transfer events. Our results suggest that DndCDEA-PbeABCD is a new type of PT-based virus resistance system, expanding the known arsenal of defence systems as well as our understanding of host-virus interactions.

Suggested Citation

  • Lei Xiong & Siyi Liu & Si Chen & Yao Xiao & Bochen Zhu & Yali Gao & Yujing Zhang & Beibei Chen & Jie Luo & Zixin Deng & Xiangdong Chen & Lianrong Wang & Shi Chen, 2019. "A new type of DNA phosphorothioation-based antiviral system in archaea," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09390-9
    DOI: 10.1038/s41467-019-09390-9
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    Cited by:

    1. Huahua Jian & Guanpeng Xu & Yi Yi & Yali Hao & Yinzhao Wang & Lei Xiong & Siyuan Wang & Shunzhang Liu & Canxing Meng & Jiahua Wang & Yue Zhang & Chao Chen & Xiaoyuan Feng & Haiwei Luo & Hao Zhang & Xi, 2021. "The origin and impeded dissemination of the DNA phosphorothioation system in prokaryotes," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    2. Xuan Zou & Xiaohong Xiao & Ziran Mo & Yashi Ge & Xing Jiang & Ruolin Huang & Mengxue Li & Zixin Deng & Shi Chen & Lianrong Wang & Sang Yup Lee, 2022. "Systematic strategies for developing phage resistant Escherichia coli strains," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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