IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v10y2019i1d10.1038_s41467-019-09280-0.html
   My bibliography  Save this article

Hippocampal CA1 replay becomes less prominent but more rigid without inputs from medial entorhinal cortex

Author

Listed:
  • Alireza Chenani

    (Ludwig-Maximilians-Universität München
    Max-Planck Institute for Psychiatry)

  • Marta Sabariego

    (University of California, San Diego)

  • Magdalene I. Schlesiger

    (University of California, San Diego
    Medical Faculty of Heidelberg University and German Cancer Research Center (DKFZ))

  • Jill K. Leutgeb

    (University of California, San Diego)

  • Stefan Leutgeb

    (University of California, San Diego
    University of California, San Diego)

  • Christian Leibold

    (Ludwig-Maximilians-Universität München
    Bernstein Center for Computational Neuroscience Munich)

Abstract

The hippocampus is an essential brain area for learning and memory. However, the network mechanisms underlying memory storage, consolidation and retrieval remain incompletely understood. Place cell sequences during theta oscillations are thought to be replayed during non-theta states to support consolidation and route planning. In animals with medial entorhinal cortex (MEC) lesions, the temporal organization of theta-related hippocampal activity is disrupted, which allows us to test whether replay is also compromised. Two different analyses—comparison of co-activation patterns between running and rest epochs and analysis of the recurrence of place cell sequences—reveal that the enhancement of replay by behavior is reduced in MEC-lesioned versus control rats. In contrast, the degree of intrinsic network structure prior and subsequent to behavior remains unaffected by MEC lesions. The MEC-dependent temporal coordination during theta states therefore appears to facilitate behavior-related plasticity, but does not disrupt pre-existing functional connectivity.

Suggested Citation

  • Alireza Chenani & Marta Sabariego & Magdalene I. Schlesiger & Jill K. Leutgeb & Stefan Leutgeb & Christian Leibold, 2019. "Hippocampal CA1 replay becomes less prominent but more rigid without inputs from medial entorhinal cortex," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09280-0
    DOI: 10.1038/s41467-019-09280-0
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-019-09280-0
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-019-09280-0?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Siavash Ahmadi & Takuya Sasaki & Marta Sabariego & Christian Leibold & Stefan Leutgeb & Jill K. Leutgeb, 2025. "Distinct roles of dentate gyrus and medial entorhinal cortex inputs for phase precession and temporal correlations in the hippocampal CA3 area," Nature Communications, Nature, vol. 16(1), pages 1-20, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09280-0. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.