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Aedes mosquitoes acquire and transmit Zika virus by breeding in contaminated aquatic environments

Author

Listed:
  • Senyan Du

    (Tsinghua University
    Tsinghua University
    Shenzhen Center for Disease Control and Prevention)

  • Yang Liu

    (Tsinghua University
    Tsinghua University)

  • Jianying Liu

    (Tsinghua University)

  • Jie Zhao

    (Tsinghua University)

  • Clara Champagne

    (UMR 8197 CNRS-ENS Ecole Normale Supérieure)

  • Liangqin Tong

    (Tsinghua University)

  • Renli Zhang

    (Shenzhen Center for Disease Control and Prevention)

  • Fuchun Zhang

    (Guangzhou Medical University)

  • Cheng-Feng Qin

    (Beijing Institute of Microbiology and Epidemiology)

  • Ping Ma

    (Tsinghua University Hospital)

  • Chun-Hong Chen

    (National Health Research Institutes, Zhunan)

  • Guodong Liang

    (National Institute for Viral Disease Control and Prevention, China CDC)

  • Qiyong Liu

    (National Institute for Communicable Disease Control and Prevention, China CDC)

  • Pei-Yong Shi

    (University of Texas Medical Branch)

  • Bernard Cazelles

    (UMR 8197 CNRS-ENS Ecole Normale Supérieure
    IRD-Sorbone Université)

  • Penghua Wang

    (the University of Connecticut Health Center)

  • Huaiyu Tian

    (Beijing Normal University)

  • Gong Cheng

    (Tsinghua University
    Tsinghua University
    Shenzhen Center for Disease Control and Prevention)

Abstract

Zika virus (ZIKV) is a mosquito-borne flavivirus that predominantly circulates between humans and Aedes mosquitoes. Clinical studies have shown that Zika viruria in patients persists for an extended period, and results in infectious virions being excreted. Here, we demonstrate that Aedes mosquitoes are permissive to ZIKV infection when breeding in urine or sewage containing low concentrations of ZIKV. Mosquito larvae and pupae, including from field Aedes aegypti can acquire ZIKV from contaminated aquatic systems, resulting in ZIKV infection of adult females. Adult mosquitoes can transmit infectious virions to susceptible type I/II interferon receptor-deficient (ifnagr-/-) C57BL/6 (AG6) mice. Furthermore, ZIKV viruria from infected AG6 mice can causes mosquito infection during the aquatic life stages. Our studies suggest that infectious urine could be a natural ZIKV source, which is potentially transmissible to mosquitoes when breeding in an aquatic environment.

Suggested Citation

  • Senyan Du & Yang Liu & Jianying Liu & Jie Zhao & Clara Champagne & Liangqin Tong & Renli Zhang & Fuchun Zhang & Cheng-Feng Qin & Ping Ma & Chun-Hong Chen & Guodong Liang & Qiyong Liu & Pei-Yong Shi & , 2019. "Aedes mosquitoes acquire and transmit Zika virus by breeding in contaminated aquatic environments," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09256-0
    DOI: 10.1038/s41467-019-09256-0
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    Cited by:

    1. Emily Ying Yang Chan & Tiffany Sze Tung Sham & Tayyab Salim Shahzada & Caroline Dubois & Zhe Huang & Sida Liu & Kevin K.C. Hung & Shelly L.A. Tse & Kin On Kwok & Pui-Hong Chung & Ryoma Kayano & Rajib , 2020. "Narrative Review on Health-EDRM Primary Prevention Measures for Vector-Borne Diseases," IJERPH, MDPI, vol. 17(16), pages 1-28, August.

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