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Coming together to define membrane contact sites

Author

Listed:
  • Luca Scorrano

    (University of Padua)

  • Maria Antonietta Matteis

    (Telethon Institute of Genetics and Medicine
    University of Napoli Federico II)

  • Scott Emr

    (Cornell University)

  • Francesca Giordano

    (Paris-Saclay University)

  • György Hajnóczky

    (Thomas Jefferson University)

  • Benoît Kornmann

    (University of Oxford, Department of Biochemistry)

  • Laura L. Lackner

    (Northwestern University)

  • Tim P. Levine

    (UCL Institute of Ophthalmology)

  • Luca Pellegrini

    (Universitè Laval)

  • Karin Reinisch

    (Yale University School of Medicine)

  • Rosario Rizzuto

    (University of Padua)

  • Thomas Simmen

    (Department of Cell Biology)

  • Harald Stenmark

    (University of Oslo, Montebello)

  • Christian Ungermann

    (University of Osnabrück)

  • Maya Schuldiner

    (Weizmann Institute of Science)

Abstract

Close proximities between organelles have been described for decades. However, only recently a specific field dealing with organelle communication at membrane contact sites has gained wide acceptance, attracting scientists from multiple areas of cell biology. The diversity of approaches warrants a unified vocabulary for the field. Such definitions would facilitate laying the foundations of this field, streamlining communication and resolving semantic controversies. This opinion, written by a panel of experts in the field, aims to provide this burgeoning area with guidelines for the experimental definition and analysis of contact sites. It also includes suggestions on how to operationally and tractably measure and analyze them with the hope of ultimately facilitating knowledge production and dissemination within and outside the field of contact-site research.

Suggested Citation

  • Luca Scorrano & Maria Antonietta Matteis & Scott Emr & Francesca Giordano & György Hajnóczky & Benoît Kornmann & Laura L. Lackner & Tim P. Levine & Luca Pellegrini & Karin Reinisch & Rosario Rizzuto &, 2019. "Coming together to define membrane contact sites," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09253-3
    DOI: 10.1038/s41467-019-09253-3
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    Cited by:

    1. Patrick A. Sandoz & Robin A. Denhardt-Eriksson & Laurence Abrami & Luciano A. Abriata & Gard Spreemann & Catherine Maclachlan & Sylvia Ho & Béatrice Kunz & Kathryn Hess & Graham Knott & Francisco S. M, 2023. "Dynamics of CLIMP-63 S-acylation control ER morphology," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Deborah Mesa & Elisa Barbieri & Andrea Raimondi & Stefano Freddi & Giorgia Miloro & Gorana Jendrisek & Giusi Caldieri & Micaela Quarto & Irene Schiano Lomoriello & Maria Grazia Malabarba & Arianna Bre, 2024. "A tripartite organelle platform links growth factor receptor signaling to mitochondrial metabolism," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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