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Perinatal factors affect the gut microbiota up to four years after birth

Author

Listed:
  • Fiona Fouhy

    (APC Microbiome Ireland
    Teagasc Food Research Centre, Moorepark, Fermoy, Co)

  • Claire Watkins

    (APC Microbiome Ireland
    Teagasc Food Research Centre, Moorepark, Fermoy, Co)

  • Cian J. Hill

    (APC Microbiome Ireland)

  • Carol-Anne O’Shea

    (Cork University Maternity Hospital)

  • Brid Nagle

    (Teagasc Food Research Centre, Moorepark, Fermoy, Co)

  • Eugene M. Dempsey

    (Cork University Maternity Hospital
    University College Cork)

  • Paul W. O’Toole

    (APC Microbiome Ireland
    University College Cork)

  • R. Paul Ross

    (APC Microbiome Ireland
    University College Cork)

  • C. Anthony Ryan

    (APC Microbiome Ireland
    Cork University Maternity Hospital)

  • Catherine Stanton

    (APC Microbiome Ireland
    Teagasc Food Research Centre, Moorepark, Fermoy, Co)

Abstract

Perinatal factors impact gut microbiota development in early life, however, little is known on the effects of these factors on microbes in later life. Here we sequence DNA from faecal samples of children over the first four years and reveal a perpetual evolution of the gut microbiota during this period. The significant impact of gestational age at birth and delivery mode on gut microbiota progression is evident in the first four years of life, while no measurable effects of antibiotics are found in the first year. Microbiota profiles are also characteristic in children dependant on gestational age and maturity. Full term delivery is characterised by Bacteroides (year one), Parabacteroides (year two) and Christensenellaceae (year four). Preterm delivery is characterised by Lactobacillus (year one), Streptococcus (year two) and Carnobacterium (year four). This study reveals that the gut retains distinct microbial profiles of perinatal factors up to four years of age.

Suggested Citation

  • Fiona Fouhy & Claire Watkins & Cian J. Hill & Carol-Anne O’Shea & Brid Nagle & Eugene M. Dempsey & Paul W. O’Toole & R. Paul Ross & C. Anthony Ryan & Catherine Stanton, 2019. "Perinatal factors affect the gut microbiota up to four years after birth," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09252-4
    DOI: 10.1038/s41467-019-09252-4
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    Cited by:

    1. Shuqin Zeng & Dhrati Patangia & Alexandre Almeida & Zhemin Zhou & Dezhi Mu & R. Paul Ross & Catherine Stanton & Shaopu Wang, 2022. "A compendium of 32,277 metagenome-assembled genomes and over 80 million genes from the early-life human gut microbiome," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Shuqin Zeng & Alexandre Almeida & Shiping Li & Junjie Ying & Hua Wang & Yi Qu & R. Paul Ross & Catherine Stanton & Zhemin Zhou & Xiaoyu Niu & Dezhi Mu & Shaopu Wang, 2024. "A metagenomic catalog of the early-life human gut virome," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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