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Facile syntheses of conjugated polymers for photothermal tumour therapy

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  • Peiyao Chen

    (University of Science and Technology of China)

  • Yinchu Ma

    (University of Science and Technology of China)

  • Zhen Zheng

    (University of Science and Technology of China)

  • Chengfan Wu

    (University of Science and Technology of China)

  • Yucai Wang

    (University of Science and Technology of China)

  • Gaolin Liang

    (University of Science and Technology of China
    Southeast University)

Abstract

Development of photothermal materials which are able to harness sunlight and convert it to thermal energy seems attractive. Besides carbon-based nanomaterials, conjugated polymers are emerging promising photothermal materials but their facile syntheses remain challenging. In this work, by modification of a CBT-Cys click condensation reaction and rational design of the starting materials, we facilely synthesize conjugated polymers poly-2-phenyl-benzobisthiazole (PPBBT) and its dihexyl derivative with good photothermal properties. Under the irradiation of either sunlight-mimicking Xe light or near-infrared laser, we verify that PPBBT has comparable photothermal heating-up speed to that of star material single-wall carbon nanotube. Moreover, PPBBT is used to fabricate water-soluble NPPPBBT nanoparticles which maintain excellent photothermal properties in vitro and photothermal therapy effect on the tumours exposed to laser irradiation. We envision that our synthetic method provides a facile approach to fabricate conjugated polymers for more promising applications in biomedicine or photovoltaics in the near future.

Suggested Citation

  • Peiyao Chen & Yinchu Ma & Zhen Zheng & Chengfan Wu & Yucai Wang & Gaolin Liang, 2019. "Facile syntheses of conjugated polymers for photothermal tumour therapy," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09226-6
    DOI: 10.1038/s41467-019-09226-6
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