IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v10y2019i1d10.1038_s41467-019-09200-2.html
   My bibliography  Save this article

Molecular mechanism for the control of virulent Toxoplasma gondii infections in wild-derived mice

Author

Listed:
  • Mateo Murillo-León

    (Medical Center University of Freiburg
    University of Freiburg
    University of Freiburg)

  • Urs B. Müller

    (University of Cologne)

  • Ines Zimmermann

    (Medical Center University of Freiburg
    University of Freiburg)

  • Shishir Singh

    (Medical Center University of Freiburg
    University of Freiburg
    University of Freiburg)

  • Pia Widdershooven

    (University of Cologne
    University of Cologne)

  • Cláudia Campos

    (Instituto Gulbenkian de Ciencia)

  • Catalina Alvarez

    (Instituto Gulbenkian de Ciencia)

  • Stephanie Könen-Waisman

    (University Hospital of Cologne)

  • Nahleen Lukes

    (University Hospital Aachen)

  • Zsolt Ruzsics

    (Medical Center University of Freiburg
    University of Freiburg)

  • Jonathan C. Howard

    (Instituto Gulbenkian de Ciencia)

  • Martin Schwemmle

    (Medical Center University of Freiburg
    University of Freiburg)

  • Tobias Steinfeldt

    (Medical Center University of Freiburg
    University of Freiburg)

Abstract

Some strains of the protozoan parasite Toxoplasma gondii (such as RH) are virulent in laboratory mice because they are not restricted by the Immunity-Related GTPase (IRG) resistance system in these mouse strains. In some wild-derived Eurasian mice (such as CIM) on the other hand, polymorphic IRG proteins inhibit the replication of such virulent T. gondii strains. Here we show that this resistance is due to direct binding of the IRG protein Irgb2-b1CIM to the T. gondii virulence effector ROP5 isoform B. The Irgb2-b1 interface of this interaction is highly polymorphic and under positive selection. South American T. gondii strains are virulent even in wild-derived Eurasian mice. We were able to demonstrate that this difference in virulence is due to polymorphic ROP5 isoforms that are not targeted by Irgb2-b1CIM, indicating co-adaptation of host cell resistance GTPases and T. gondii virulence effectors.

Suggested Citation

  • Mateo Murillo-León & Urs B. Müller & Ines Zimmermann & Shishir Singh & Pia Widdershooven & Cláudia Campos & Catalina Alvarez & Stephanie Könen-Waisman & Nahleen Lukes & Zsolt Ruzsics & Jonathan C. How, 2019. "Molecular mechanism for the control of virulent Toxoplasma gondii infections in wild-derived mice," Nature Communications, Nature, vol. 10(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09200-2
    DOI: 10.1038/s41467-019-09200-2
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-019-09200-2
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-019-09200-2?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09200-2. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.