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A Hox-TALE regulatory circuit for neural crest patterning is conserved across vertebrates

Author

Listed:
  • Hugo J. Parker

    (Stowers Institute for Medical Research)

  • Bony De Kumar

    (Stowers Institute for Medical Research)

  • Stephen A. Green

    (California Institute of Technology)

  • Karin D. Prummel

    (University of Zurich)

  • Christopher Hess

    (University of Zurich)

  • Charles K. Kaufman

    (Washington University in Saint Louis)

  • Christian Mosimann

    (University of Zurich)

  • Leanne M. Wiedemann

    (Stowers Institute for Medical Research
    Kansas University Medical Center)

  • Marianne E. Bronner

    (California Institute of Technology)

  • Robb Krumlauf

    (Stowers Institute for Medical Research
    Kansas University Medical Center)

Abstract

In jawed vertebrates (gnathostomes), Hox genes play an important role in patterning head and jaw formation, but mechanisms coupling Hox genes to neural crest (NC) are unknown. Here we use cross-species regulatory comparisons between gnathostomes and lamprey, a jawless extant vertebrate, to investigate conserved ancestral mechanisms regulating Hox2 genes in NC. Gnathostome Hoxa2 and Hoxb2 NC enhancers mediate equivalent NC expression in lamprey and gnathostomes, revealing ancient conservation of Hox upstream regulatory components in NC. In characterizing a lamprey hoxα2 NC/hindbrain enhancer, we identify essential Meis, Pbx, and Hox binding sites that are functionally conserved within Hoxa2/Hoxb2 NC enhancers. This suggests that the lamprey hoxα2 enhancer retains ancestral activity and that Hoxa2/Hoxb2 NC enhancers are ancient paralogues, which diverged in hindbrain and NC activities. This identifies an ancestral mechanism for Hox2 NC regulation involving a Hox-TALE regulatory circuit, potentiated by inputs from Meis and Pbx proteins and Hox auto-/cross-regulatory interactions.

Suggested Citation

  • Hugo J. Parker & Bony De Kumar & Stephen A. Green & Karin D. Prummel & Christopher Hess & Charles K. Kaufman & Christian Mosimann & Leanne M. Wiedemann & Marianne E. Bronner & Robb Krumlauf, 2019. "A Hox-TALE regulatory circuit for neural crest patterning is conserved across vertebrates," Nature Communications, Nature, vol. 10(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09197-8
    DOI: 10.1038/s41467-019-09197-8
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    Cited by:

    1. Marta Losa & Iros Barozzi & Marco Osterwalder & Viviana Hermosilla-Aguayo & Angela Morabito & Brandon H. Chacón & Peyman Zarrineh & Ausra Girdziusaite & Jean Denis Benazet & Jianjian Zhu & Susan Macke, 2023. "A spatio-temporally constrained gene regulatory network directed by PBX1/2 acquires limb patterning specificity via HAND2," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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