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A highly selective and recyclable NO-responsive nanochannel based on a spiroring opening−closing reaction strategy

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  • Yao Sun

    (Central China Normal University)

  • Sen Chen

    (Central China Normal University)

  • Xiaoya Chen

    (Hunan University)

  • Yuling Xu

    (Central China Normal University)

  • Siyun Zhang

    (Central China Normal University)

  • Qingying Ouyang

    (Central China Normal University)

  • Guangfu Yang

    (Central China Normal University)

  • Haibing Li

    (Central China Normal University)

Abstract

Endogenous nitric oxide (NO) is an important messenger molecule, which can directly activate K+ transmission and cause relaxation of vascular smooth muscle. Here, inspired by the K+ channel of smooth muscle cells, we report, a novel NO-regulated artificial nanochannel based on a spiro ring opening−closing reaction strategy. This nanofluidic diode system shows an outstanding NO selective response owing to the specific reaction between o-phenylenediamine (OPD) and NO on the channel surface with high ion rectification ratio (~6.7) and ion gating ratio (~4). Moreover, this NO gating system exhibits excellent reversibility and stability as well as high selectivity response. This system not only helps us understand the process of NO directly regulating biological ion channels, but also has potential application value in the field of biosensors.

Suggested Citation

  • Yao Sun & Sen Chen & Xiaoya Chen & Yuling Xu & Siyun Zhang & Qingying Ouyang & Guangfu Yang & Haibing Li, 2019. "A highly selective and recyclable NO-responsive nanochannel based on a spiroring opening−closing reaction strategy," Nature Communications, Nature, vol. 10(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09163-4
    DOI: 10.1038/s41467-019-09163-4
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    Cited by:

    1. Xiaoming Liu & Fengyu Liu & Hemani Chhabra & Christopher Maffeo & Zhuo Chen & Qiang Huang & Aleksei Aksimentiev & Tatsuo Arai, 2024. "A lumen-tunable triangular DNA nanopore for molecular sensing and cross-membrane transport," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    2. Dan Zhang & Yongjie Sun & Zhichao Wang & Fang Liu & Xuanjun Zhang, 2023. "Switchable biomimetic nanochannels for on-demand SO2 detection by light-controlled photochromism," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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