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Control of capillary behavior through target-responsive hydrogel permeability alteration for sensitive visual quantitative detection

Author

Listed:
  • Yansheng Li

    (University of Science and Technology Beijing)

  • Yanli Ma

    (Xiamen University)

  • Xiangyu Jiao

    (University of Science and Technology Beijing)

  • Tingyu Li

    (Xiamen University)

  • Zhehao Lv

    (Xiamen University)

  • Chaoyong James Yang

    (Xiamen University
    Renji Hospital, Shanghai Jiao Tong University, School of Medicine)

  • Xueji Zhang

    (University of Science and Technology Beijing)

  • Yongqiang Wen

    (University of Science and Technology Beijing)

Abstract

DNA hydrogels have received considerable attention in analytical science, however, some limitations still exist in the applications of intelligent hydrogels. In this paper, we describe a way to prepare gel film in a capillary tube based on the thermal reversible principle of DNA hydrogel and the principle of capillary action. Because of the slight change in the internal structure of gel, its permeability can be increased by the addition of some specific targets. The capillary behavior is thus changed due to the different permeability of the hydrogel film. The duration time of the target solution flowing through the capillary tube with a specified length is used to quantify this change. With this proposed method, ultra-trace DNA hydrogel (0.01 μL) is sufficient to realize the sensitive detection of cocaine without the aid of other instruments, which has a low detection limit (1.17 nM) and good selectivity.

Suggested Citation

  • Yansheng Li & Yanli Ma & Xiangyu Jiao & Tingyu Li & Zhehao Lv & Chaoyong James Yang & Xueji Zhang & Yongqiang Wen, 2019. "Control of capillary behavior through target-responsive hydrogel permeability alteration for sensitive visual quantitative detection," Nature Communications, Nature, vol. 10(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-08952-1
    DOI: 10.1038/s41467-019-08952-1
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