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Emerging roles of eraser enzymes in the dynamic control of protein ADP-ribosylation

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  • Julia O’Sullivan

    (Centre de Recherche du Centre Hospitalier Universitaire de Québec-Université Laval, HDQ Pavilion, Oncology Division
    Université Laval)

  • Maria Tedim Ferreira

    (Centre de Recherche du Centre Hospitalier Universitaire de Québec-Université Laval, HDQ Pavilion, Oncology Division
    Université Laval
    Centre de Recherche du Centre Hospitalier Universitaire de Québec-Université Laval, CHUL Pavilion, Oncology division)

  • Jean-Philippe Gagné

    (Université Laval
    Centre de Recherche du Centre Hospitalier Universitaire de Québec-Université Laval, CHUL Pavilion, Oncology division)

  • Ajit K. Sharma

    (University of Alberta)

  • Michael J. Hendzel

    (University of Alberta
    University of Alberta)

  • Jean-Yves Masson

    (Centre de Recherche du Centre Hospitalier Universitaire de Québec-Université Laval, HDQ Pavilion, Oncology Division
    Université Laval
    Centre de Recherche sur le Cancer de l’Université Laval)

  • Guy G. Poirier

    (Université Laval
    Centre de Recherche du Centre Hospitalier Universitaire de Québec-Université Laval, CHUL Pavilion, Oncology division
    Centre de Recherche sur le Cancer de l’Université Laval)

Abstract

Protein ADP-ribosylation is essential for the regulation of several cellular pathways, enabling dynamic responses to diverse pathophysiological conditions. It is modulated through a dynamic interplay between ADP-ribose readers, writers and erasers. While ADP-ribose synthesis has been studied and reviewed extensively, ADP-ribose processing by erasing enzymes has received comparably less attention. However, major progress in the mass spectrometric identification of ADP-ribosylated residues and the biochemical characterization of ADP-ribose erasers has substantially expanded our knowledge of ADP-ribosylation dynamics. Herein, we describe recent insights into the biology of ADP-ribose erasers and discuss the intricately orchestrated cellular processes to switch off ADP-ribose-dependent mechanisms.

Suggested Citation

  • Julia O’Sullivan & Maria Tedim Ferreira & Jean-Philippe Gagné & Ajit K. Sharma & Michael J. Hendzel & Jean-Yves Masson & Guy G. Poirier, 2019. "Emerging roles of eraser enzymes in the dynamic control of protein ADP-ribosylation," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-08859-x
    DOI: 10.1038/s41467-019-08859-x
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