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Impact of pre-existing dengue immunity on human antibody and memory B cell responses to Zika

Author

Listed:
  • Paulina Andrade

    (University of California, Berkeley
    Colegio de Ciencias Biológicas y Ambientales, Universidad San Francisco de Quito)

  • Ciara Gimblet-Ochieng

    (University of North Carolina)

  • Faraz Modirian

    (University of California, Berkeley)

  • Matthew Collins

    (University of North Carolina
    Emory University)

  • Maritza Cárdenas

    (University of California, Berkeley)

  • Leah C. Katzelnick

    (University of California, Berkeley)

  • Magelda Montoya

    (University of California, Berkeley)

  • Daniela Michlmayr

    (University of California, Berkeley)

  • Guillermina Kuan

    (Centro de Salud Sócrates Flores Vivas, Ministry of Health
    Sustainable Sciences Institute)

  • Angel Balmaseda

    (Sustainable Sciences Institute
    Centro Nacional de Diagnóstico y Referencia, Ministry of Health)

  • Josefina Coloma

    (University of California, Berkeley)

  • Aravinda M. Silva

    (University of North Carolina)

  • Eva Harris

    (University of California, Berkeley)

Abstract

Little is known about enduring memory B cell (MBC) responses to Zika virus (ZIKV) and their relationship with circulating antibodies. Here we comprehensively assess MBC frequency and specificity alongside serum binding and neutralizing antibody responses to ZIKV ~2 weeks and ~8 months postinfection in 31 pediatric subjects with 0, 1 or >1 prior infections with the related dengue virus (DENV). ZIKV infection elicits a robust type-specific MBC response, and the majority of late convalescent anti-ZIKV serum neutralizing activity is attributable to ZIKV-specific antibodies. The number of prior DENV infections does not influence type-specific or cross-reactive MBC responses, although ZIKV has the highest cross-reactivity with DENV3. DENV cross-reactive MBCs expanded by ZIKV infection decline in number and proportion by late convalescence. Finally, ZIKV induces greater cross-reactivity in the MBC pool than in serum antibodies. Our data suggest immunity to DENV only modestly shapes breadth and magnitude of enduring ZIKV antibody responses.

Suggested Citation

  • Paulina Andrade & Ciara Gimblet-Ochieng & Faraz Modirian & Matthew Collins & Maritza Cárdenas & Leah C. Katzelnick & Magelda Montoya & Daniela Michlmayr & Guillermina Kuan & Angel Balmaseda & Josefina, 2019. "Impact of pre-existing dengue immunity on human antibody and memory B cell responses to Zika," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-08845-3
    DOI: 10.1038/s41467-019-08845-3
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    Cited by:

    1. Francesco Pinotti & Marta Giovanetti & Maricelia Maia Lima & Erenilde Marques Cerqueira & Luiz C. J. Alcantara & Sunetra Gupta & Mario Recker & José Lourenço, 2024. "Shifting patterns of dengue three years after Zika virus emergence in Brazil," Nature Communications, Nature, vol. 15(1), pages 1-10, December.

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