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Dynamic molecular changes during the first week of human life follow a robust developmental trajectory

Author

Listed:
  • Amy H. Lee

    (University of British Columbia)

  • Casey P. Shannon

    (PROOF Centre of Excellence)

  • Nelly Amenyogbe

    (University of British Columbia
    Telethon Kids Institute)

  • Tue B. Bennike

    (Boston Children’s Hospital
    Boston Children’s Hospital
    Harvard Medical School)

  • Joann Diray-Arce

    (Boston Children’s Hospital
    Harvard Medical School)

  • Olubukola T. Idoko

    (Vaccines & Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine
    Medical Center of the University of Munich (LMU))

  • Erin E. Gill

    (University of British Columbia)

  • Rym Ben-Othman

    (University of British Columbia)

  • William S. Pomat

    (Papua New Guinea Institute of Medical Research)

  • Simon D. Haren

    (Boston Children’s Hospital
    Harvard Medical School)

  • Kim-Anh Lê Cao

    (The University of Melbourne)

  • Momoudou Cox

    (Vaccines & Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine)

  • Alansana Darboe

    (Vaccines & Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine)

  • Reza Falsafi

    (University of British Columbia)

  • Davide Ferrari

    (The University of Melbourne)

  • Daniel J. Harbeson

    (University of British Columbia)

  • Daniel He

    (PROOF Centre of Excellence)

  • Cai Bing

    (University of British Columbia)

  • Samuel J. Hinshaw

    (University of British Columbia
    BCCA)

  • Jorjoh Ndure

    (Vaccines & Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine)

  • Jainaba Njie-Jobe

    (Vaccines & Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine)

  • Matthew A. Pettengill

    (Boston Children’s Hospital)

  • Peter C. Richmond

    (Division of Paediatrics, School of Medicine, University of Western Australia
    University of Western Australia Perth)

  • Rebecca Ford

    (Papua New Guinea Institute of Medical Research)

  • Gerard Saleu

    (Papua New Guinea Institute of Medical Research)

  • Geraldine Masiria

    (Papua New Guinea Institute of Medical Research)

  • John Paul Matlam

    (Papua New Guinea Institute of Medical Research)

  • Wendy Kirarock

    (Papua New Guinea Institute of Medical Research)

  • Elishia Roberts

    (Vaccines & Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine)

  • Mehrnoush Malek

    (BC Cancer Agency)

  • Guzmán Sanchez-Schmitz

    (Boston Children’s Hospital
    Harvard Medical School)

  • Amrit Singh

    (PROOF Centre of Excellence
    University of British Columbia)

  • Asimenia Angelidou

    (Boston Children’s Hospital
    Harvard Medical School
    Boston Children’s Hospital)

  • Kinga K. Smolen

    (Boston Children’s Hospital
    Harvard Medical School)

  • Ryan R. Brinkman

    (BC Cancer Agency
    University of British Columbia)

  • Al Ozonoff

    (Boston Children’s Hospital
    Harvard Medical School
    Boston Children’s Hospital)

  • Robert E. W. Hancock

    (University of British Columbia)

  • Anita H. J. Biggelaar

    (University of Western Australia Perth)

  • Hanno Steen

    (Boston Children’s Hospital
    Boston Children’s Hospital
    Vaccines & Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine)

  • Scott J. Tebbutt

    (PROOF Centre of Excellence
    UBC Centre for Heart and Lung Innovation
    UBC)

  • Beate Kampmann

    (Vaccines & Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine
    London School of Hygiene and Tropical Medicine)

  • Ofer Levy

    (Boston Children’s Hospital
    Harvard Medical School
    Broad Institute of MIT & Harvard)

  • Tobias R. Kollmann

    (University of British Columbia
    University of British Columbia
    Telethon Kids Institute)

Abstract

Systems biology can unravel complex biology but has not been extensively applied to human newborns, a group highly vulnerable to a wide range of diseases. We optimized methods to extract transcriptomic, proteomic, metabolomic, cytokine/chemokine, and single cell immune phenotyping data from

Suggested Citation

  • Amy H. Lee & Casey P. Shannon & Nelly Amenyogbe & Tue B. Bennike & Joann Diray-Arce & Olubukola T. Idoko & Erin E. Gill & Rym Ben-Othman & William S. Pomat & Simon D. Haren & Kim-Anh Lê Cao & Momoudou, 2019. "Dynamic molecular changes during the first week of human life follow a robust developmental trajectory," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-08794-x
    DOI: 10.1038/s41467-019-08794-x
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    Citations

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    Cited by:

    1. David Martino & Nina Kresoje & Nelly Amenyogbe & Rym Ben-Othman & Bing Cai & Mandy Lo & Olubukola Idoko & Oludare A. Odumade & Reza Falsafi & Travis M. Blimkie & Andy An & Casey P. Shannon & Sebastian, 2024. "DNA Methylation signatures underpinning blood neutrophil to lymphocyte ratio during first week of human life," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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