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Highly efficient photothermal nanoagent achieved by harvesting energy via excited-state intramolecular motion within nanoparticles

Author

Listed:
  • Zheng Zhao

    (The Hong Kong University of Science and Technology)

  • Chao Chen

    (Nankai University)

  • Wenting Wu

    (Chinese Academy of Science)

  • Fenfen Wang

    (Nankai University)

  • Lili Du

    (The University of Hong Kong
    Jiangsu University)

  • Xiaoyan Zhang

    (Nankai University)

  • Yu Xiong

    (Shenzhen Research Institute)

  • Xuewen He

    (The Hong Kong University of Science and Technology)

  • Yuanjing Cai

    (The Hong Kong University of Science and Technology)

  • Ryan T. K. Kwok

    (The Hong Kong University of Science and Technology)

  • Jacky W. Y. Lam

    (The Hong Kong University of Science and Technology)

  • Xike Gao

    (Chinese Academy of Science)

  • Pingchuan Sun

    (Nankai University)

  • David Lee Phillips

    (The University of Hong Kong)

  • Dan Ding

    (Nankai University)

  • Ben Zhong Tang

    (The Hong Kong University of Science and Technology
    Shenzhen Research Institute)

Abstract

The exciting applications of molecular motion are still limited and are in urgent pursuit, although some fascinating concepts such as molecular motors and molecular machines have been proposed for years. Utilizing molecular motion in a nanoplatform for practical application has been scarcely explored due to some unconquered challenges such as how to achieve effective molecular motion in the aggregate state within nanoparticles. Here, we introduce a class of near infrared-absorbing organic molecules with intramolecular motion-induced photothermy inside nanoparticles, which enables most absorbed light energy to dissipate as heat. Such a property makes the nanoparticles a superior photoacoustic imaging agent compared to widely used methylene blue and semiconducting polymer nanoparticles and allow them for high-contrast photoacoustic imaging of tumours in live mice. This study not only provides a strategy for developing advanced photothermal/photoacoustic imaging nanoagents, but also enables molecular motion in a nanoplatform to find a way for practical application.

Suggested Citation

  • Zheng Zhao & Chao Chen & Wenting Wu & Fenfen Wang & Lili Du & Xiaoyan Zhang & Yu Xiong & Xuewen He & Yuanjing Cai & Ryan T. K. Kwok & Jacky W. Y. Lam & Xike Gao & Pingchuan Sun & David Lee Phillips & , 2019. "Highly efficient photothermal nanoagent achieved by harvesting energy via excited-state intramolecular motion within nanoparticles," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-08722-z
    DOI: 10.1038/s41467-019-08722-z
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    Cited by:

    1. Iryna Yaremchuk & Tetiana Bulavinets & Yuriy Smachylo & Yuriy Mysiuk & Volodymyr Fitio & Pavlo Stakhira, 2024. "Modeling of the tunable plasmonic properties of spherical and ellipsoidal silver nanoparticles in the matrix of an organic semiconductor," Technology audit and production reserves, PC TECHNOLOGY CENTER, vol. 5(1(79)), pages 12-18, October.

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