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Noninvasive ultrasound stimulation of the spleen to treat inflammatory arthritis

Author

Listed:
  • Daniel P. Zachs

    (University of Minnesota)

  • Sarah J. Offutt

    (Medtronic plc)

  • Rachel S. Graham

    (University of Minnesota)

  • Yohan Kim

    (Medtronic plc)

  • Jerel Mueller

    (Medtronic plc)

  • Jennifer L. Auger

    (University of Minnesota)

  • Nathaniel J. Schuldt

    (University of Minnesota)

  • Claire R. W. Kaiser

    (University of Minnesota)

  • Abigail P. Heiller

    (University of Minnesota)

  • Raini Dutta

    (University of Minnesota)

  • Hongsun Guo

    (University of Minnesota)

  • Jamu K. Alford

    (Medtronic plc)

  • Bryce A. Binstadt

    (University of Minnesota)

  • Hubert H. Lim

    (University of Minnesota
    University of Minnesota
    University of Minnesota)

Abstract

Targeted noninvasive control of the nervous system and end-organs may enable safer and more effective treatment of multiple diseases compared to invasive devices or systemic medications. One target is the cholinergic anti-inflammatory pathway that consists of the vagus nerve to spleen circuit, which has been stimulated with implantable devices to improve autoimmune conditions such as rheumatoid arthritis. Here we report that daily noninvasive ultrasound (US) stimulation targeting the spleen significantly reduces disease severity in a mouse model of inflammatory arthritis. Improvements are observed only with specific parameters, in which US can provide both protective and therapeutic effects. Single cell RNA sequencing of splenocytes and experiments in genetically-immunodeficient mice reveal the importance of both T and B cell populations in the anti-inflammatory pathway. These findings demonstrate the potential for US stimulation of the spleen to treat inflammatory diseases.

Suggested Citation

  • Daniel P. Zachs & Sarah J. Offutt & Rachel S. Graham & Yohan Kim & Jerel Mueller & Jennifer L. Auger & Nathaniel J. Schuldt & Claire R. W. Kaiser & Abigail P. Heiller & Raini Dutta & Hongsun Guo & Jam, 2019. "Noninvasive ultrasound stimulation of the spleen to treat inflammatory arthritis," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-08721-0
    DOI: 10.1038/s41467-019-08721-0
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    Cited by:

    1. Kang Su & Jingwei Liu & Xiaoqi Ren & Yingxiang Huo & Guanglong Du & Wei Zhao & Xueqian Wang & Bin Liang & Di Li & Peter Xiaoping Liu, 2024. "A fully autonomous robotic ultrasound system for thyroid scanning," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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