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Versatile kit of robust nanoshapes self-assembling from RNA and DNA modules

Author

Listed:
  • Alba Monferrer

    (University of California)

  • Douglas Zhang

    (University of California)

  • Alexander J. Lushnikov

    (University of Nebraska Medical Center)

  • Thomas Hermann

    (University of California
    University of California)

Abstract

DNA and RNA have emerged as a material for nanotechnology applications that take advantage of the nucleic acids’ ability to encode folding and programmable self-assembly through mainly base pairing. The two types of nucleic acid have rarely been used in combination to enhance structural diversity or for partitioning of functional and architectural roles. Here, we report a design and screening strategy to integrate combinations of RNA motifs as architectural joints and DNA building blocks as functional modules for programmable self-assembly of a versatile toolkit of polygonal nucleic acid nanoshapes. Clean incorporation of diverse DNA modules with various topologies attest to the extraordinary robustness of the RNA-DNA hybrid framework. The design and screening strategy enables systematic development of RNA-DNA hybrid nanoshapes as programmable platforms for applications in molecular recognition, sensor and catalyst development as well as protein interaction studies.

Suggested Citation

  • Alba Monferrer & Douglas Zhang & Alexander J. Lushnikov & Thomas Hermann, 2019. "Versatile kit of robust nanoshapes self-assembling from RNA and DNA modules," Nature Communications, Nature, vol. 10(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-08521-6
    DOI: 10.1038/s41467-019-08521-6
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    Cited by:

    1. Molly F. Parsons & Matthew F. Allan & Shanshan Li & Tyson R. Shepherd & Sakul Ratanalert & Kaiming Zhang & Krista M. Pullen & Wah Chiu & Silvi Rouskin & Mark Bathe, 2023. "3D RNA-scaffolded wireframe origami," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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