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KDEL receptor regulates secretion by lysosome relocation- and autophagy-dependent modulation of lipid-droplet turnover

Author

Listed:
  • Diego Tapia

    (Universidad San Sebastián
    Universidad Andrés Bello)

  • Tomás Jiménez

    (Universidad San Sebastián
    Universidad Andrés Bello)

  • Constanza Zamora

    (Universidad San Sebastián
    Universidad Andrés Bello)

  • Javier Espinoza

    (Universidad Andrés Bello)

  • Riccardo Rizzo

    (Istituto di Biochimica delle Proteine (IBP))

  • Alexis González-Cárdenas

    (Universidad Austral de Chile)

  • Danitza Fuentes

    (Pontificia Universidad Católica de Chile)

  • Sergio Hernández

    (Universidad San Sebastián)

  • Viviana A. Cavieres

    (Universidad San Sebastián
    Universidad Austral de Chile)

  • Andrea Soza

    (Universidad San Sebastián
    Pontificia Universidad Católica de Chile)

  • Fanny Guzmán

    (Fraunhofer Chile Research
    Pontificia Universidad Católica de Valparaíso)

  • Gloria Arriagada

    (Universidad Andrés Bello)

  • María Isabel Yuseff

    (Pontificia Universidad Católica de Chile)

  • Gonzalo A. Mardones

    (Universidad San Sebastián
    Universidad Austral de Chile)

  • Patricia V. Burgos

    (Universidad San Sebastián
    Pontificia Universidad Católica de Chile)

  • Alberto Luini

    (Istituto di Biochimica delle Proteine (IBP))

  • Alfonso González

    (Universidad San Sebastián
    Pontificia Universidad Católica de Chile
    Fundación Ciencia y Vida)

  • Jorge Cancino

    (Universidad San Sebastián)

Abstract

Inter-organelle signalling has essential roles in cell physiology encompassing cell metabolism, aging and temporal adaptation to external and internal perturbations. How such signalling coordinates different organelle functions within adaptive responses remains unknown. Membrane traffic is a fundamental process in which membrane fluxes need to be sensed for the adjustment of cellular requirements and homeostasis. Studying endoplasmic reticulum-to-Golgi trafficking, we found that Golgi-based, KDEL receptor-dependent signalling promotes lysosome repositioning to the perinuclear area, involving a complex process intertwined to autophagy, lipid-droplet turnover and Golgi-mediated secretion that engages the microtubule motor protein dynein-LRB1 and the autophagy cargo receptor p62/SQSTM1. This process, here named ‘traffic-induced degradation response for secretion’ (TIDeRS) discloses a cellular mechanism by which nutrient and membrane sensing machineries cooperate to sustain Golgi-dependent protein secretion.

Suggested Citation

  • Diego Tapia & Tomás Jiménez & Constanza Zamora & Javier Espinoza & Riccardo Rizzo & Alexis González-Cárdenas & Danitza Fuentes & Sergio Hernández & Viviana A. Cavieres & Andrea Soza & Fanny Guzmán & G, 2019. "KDEL receptor regulates secretion by lysosome relocation- and autophagy-dependent modulation of lipid-droplet turnover," Nature Communications, Nature, vol. 10(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-08501-w
    DOI: 10.1038/s41467-019-08501-w
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    Cited by:

    1. Yun Lan & Sophie Wilhelmina Leur & Julia Ayano Fernando & Ho Him Wong & Martin Kampmann & Lewis Siu & Jingshu Zhang & Mingyuan Li & John M. Nicholls & Sumana Sanyal, 2023. "Viral subversion of selective autophagy is critical for biogenesis of virus replication organelles," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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