Author
Listed:
- Marc G. Chevrette
(University of Wisconsin-Madison
University of Wisconsin-Madison)
- Caitlin M. Carlson
(University of Wisconsin-Madison)
- Humberto E. Ortega
(University of São Paulo)
- Chris Thomas
(University of Wisconsin-Madison)
- Gene E. Ananiev
(University of Wisconsin-Madison)
- Kenneth J. Barns
(University of Wisconsin-Madison)
- Adam J. Book
(University of Wisconsin-Madison)
- Julian Cagnazzo
(University of Wisconsin-Madison)
- Camila Carlos
(University of Wisconsin-Madison)
- Will Flanigan
(University of Wisconsin-Madison)
- Kirk J. Grubbs
(University of Wisconsin-Madison)
- Heidi A. Horn
(University of Wisconsin-Madison)
- F. Michael Hoffmann
(University of Wisconsin-Madison)
- Jonathan L. Klassen
(University of Connecticut)
- Jennifer J. Knack
(University of Minnesota-Duluth)
- Gina R. Lewin
(Georgia Institute of Technology)
- Bradon R. McDonald
(University of Wisconsin-Madison)
- Laura Muller
(University of Wisconsin-Madison)
- Weilan G. P. Melo
(University of São Paulo)
- Adrián A. Pinto-Tomás
(University of Costa Rica)
- Amber Schmitz
(University of Wisconsin-Madison)
- Evelyn Wendt-Pienkowski
(University of Wisconsin-Madison)
- Scott Wildman
(University of Wisconsin-Madison)
- Miao Zhao
(University of Wisconsin School of Medicine and Public Health)
- Fan Zhang
(University of Wisconsin-Madison)
- Tim S. Bugni
(University of Wisconsin-Madison)
- David R. Andes
(University of Wisconsin School of Medicine and Public Health)
- Monica T. Pupo
(University of São Paulo)
- Cameron R. Currie
(University of Wisconsin-Madison)
Abstract
Antimicrobial resistance is a global health crisis and few novel antimicrobials have been discovered in recent decades. Natural products, particularly from Streptomyces, are the source of most antimicrobials, yet discovery campaigns focusing on Streptomyces from the soil largely rediscover known compounds. Investigation of understudied and symbiotic sources has seen some success, yet no studies have systematically explored microbiomes for antimicrobials. Here we assess the distinct evolutionary lineages of Streptomyces from insect microbiomes as a source of new antimicrobials through large-scale isolations, bioactivity assays, genomics, metabolomics, and in vivo infection models. Insect-associated Streptomyces inhibit antimicrobial-resistant pathogens more than soil Streptomyces. Genomics and metabolomics reveal their diverse biosynthetic capabilities. Further, we describe cyphomycin, a new molecule active against multidrug resistant fungal pathogens. The evolutionary trajectories of Streptomyces from the insect microbiome influence their biosynthetic potential and ability to inhibit resistant pathogens, supporting the promise of this source in augmenting future antimicrobial discovery.
Suggested Citation
Marc G. Chevrette & Caitlin M. Carlson & Humberto E. Ortega & Chris Thomas & Gene E. Ananiev & Kenneth J. Barns & Adam J. Book & Julian Cagnazzo & Camila Carlos & Will Flanigan & Kirk J. Grubbs & Heid, 2019.
"The antimicrobial potential of Streptomyces from insect microbiomes,"
Nature Communications, Nature, vol. 10(1), pages 1-11, December.
Handle:
RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-08438-0
DOI: 10.1038/s41467-019-08438-0
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