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The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope

Author

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  • Yan Wang

    (University of Chinese Academy of Sciences)

  • Yanyan Chen

    (University of Chinese Academy of Sciences)

  • Juan Chen

    (Shanghai Jiao Tong University School of Medicine
    Shanghai Institute of Precision Medicine)

  • Lijun Wang

    (University of Chinese Academy of Sciences)

  • Leitong Nie

    (Huazhong Agriculture University)

  • Juanjuan Long

    (University of Chinese Academy of Sciences)

  • Haishuang Chang

    (Shanghai Jiao Tong University School of Medicine
    Shanghai Institute of Precision Medicine)

  • Jian Wu

    (Shanghai Jiao Tong University School of Medicine
    Shanghai Institute of Precision Medicine)

  • Chenhui Huang

    (Shanghai Jiao Tong University School of Medicine
    Shanghai Institute of Precision Medicine)

  • Ming Lei

    (Shanghai Jiao Tong University School of Medicine
    Shanghai Institute of Precision Medicine
    Shanghai Jiao Tong University School of Medicine)

Abstract

During meiotic prophase I, telomeres attach to and move on the nuclear envelope (NE), regulating chromosome movement to promote homologous pairing. Meiosis-specific proteins TERB1, TERB2 and MAJIN play a key role in this process. Here, we report the crystal structures of human TERB1-TERB2 and TERB2-MAJIN subcomplexes. Specific disruption of the TERB1-TERB2 or the TERB2-MAJIN interaction in the mouse Terb2 gene abolishes the telomere attachment to the NE and causes aberrant homologous pairing and disordered synapsis. In addition, depletion of SUN1 also partially disrupts the telomere-NE connection. We propose that the telomere-TRF1-TERB1-TERB2-MAJIN-NE interaction network and the telomere-LINC complex connection are likely two separate but cooperative pathways to stably recruit telomeres to the NE in meiosis prophase I. Our work provides a molecular model of the connection between telomeres and the NE and reveals the correlation between aberrant synapsis and the defective telomere attachment to the NE.

Suggested Citation

  • Yan Wang & Yanyan Chen & Juan Chen & Lijun Wang & Leitong Nie & Juanjuan Long & Haishuang Chang & Jian Wu & Chenhui Huang & Ming Lei, 2019. "The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope," Nature Communications, Nature, vol. 10(1), pages 1-19, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-08437-1
    DOI: 10.1038/s41467-019-08437-1
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    Cited by:

    1. Laurence Cromer & Mariana Tiscareno-Andrade & Sandrine Lefranc & Aurélie Chambon & Aurélie Hurel & Manon Brogniez & Julie Guérin & Ivan Masson & Gabriele Adam & Delphine Charif & Philippe Andrey & Mat, 2024. "Rapid meiotic prophase chromosome movements in Arabidopsis thaliana are linked to essential reorganization at the nuclear envelope," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

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