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Ingestible hydrogel device

Author

Listed:
  • Xinyue Liu

    (Massachusetts Institute of Technology)

  • Christoph Steiger

    (Massachusetts Institute of Technology
    Harvard Medical School)

  • Shaoting Lin

    (Massachusetts Institute of Technology)

  • German Alberto Parada

    (Massachusetts Institute of Technology
    Massachusetts Institute of Technology)

  • Ji Liu

    (Massachusetts Institute of Technology)

  • Hon Fai Chan

    (Massachusetts Institute of Technology
    The Chinese University of Hong Kong
    The Chinese University of Hong Kong)

  • Hyunwoo Yuk

    (Massachusetts Institute of Technology)

  • Nhi V. Phan

    (Massachusetts Institute of Technology)

  • Joy Collins

    (Massachusetts Institute of Technology)

  • Siddartha Tamang

    (Massachusetts Institute of Technology)

  • Giovanni Traverso

    (Massachusetts Institute of Technology
    Massachusetts Institute of Technology
    Harvard Medical School
    Massachusetts Institute of Technology)

  • Xuanhe Zhao

    (Massachusetts Institute of Technology
    Massachusetts Institute of Technology)

Abstract

Devices that interact with living organisms are typically made of metals, silicon, ceramics, and plastics. Implantation of such devices for long-term monitoring or treatment generally requires invasive procedures. Hydrogels offer new opportunities for human-machine interactions due to their superior mechanical compliance and biocompatibility. Additionally, oral administration, coupled with gastric residency, serves as a non-invasive alternative to implantation. Achieving gastric residency with hydrogels requires the hydrogels to swell very rapidly and to withstand gastric mechanical forces over time. However, high swelling ratio, high swelling speed, and long-term robustness do not coexist in existing hydrogels. Here, we introduce a hydrogel device that can be ingested as a standard-sized pill, swell rapidly into a large soft sphere, and maintain robustness under repeated mechanical loads in the stomach for up to one month. Large animal tests support the exceptional performance of the ingestible hydrogel device for long-term gastric retention and physiological monitoring.

Suggested Citation

  • Xinyue Liu & Christoph Steiger & Shaoting Lin & German Alberto Parada & Ji Liu & Hon Fai Chan & Hyunwoo Yuk & Nhi V. Phan & Joy Collins & Siddartha Tamang & Giovanni Traverso & Xuanhe Zhao, 2019. "Ingestible hydrogel device," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-08355-2
    DOI: 10.1038/s41467-019-08355-2
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    Cited by:

    1. Jing Chen & Yiyang Gao & Lei Shi & Wei Yu & Zongjie Sun & Yifan Zhou & Shuang Liu & Heng Mao & Dongyang Zhang & Tongqing Lu & Quan Chen & Demei Yu & Shujiang Ding, 2022. "Phase-locked constructing dynamic supramolecular ionic conductive elastomers with superior toughness, autonomous self-healing and recyclability," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Kewang Nan & Kiwan Wong & Dengfeng Li & Binbin Ying & James C. McRae & Vivian R. Feig & Shubing Wang & Ningjie Du & Yuelong Liang & Qijiang Mao & Enjie Zhou & Yonglin Chen & Lei Sang & Kuanming Yao & , 2024. "An ingestible, battery-free, tissue-adhering robotic interface for non-invasive and chronic electrostimulation of the gut," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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