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Inactivating hepatitis C virus in donor lungs using light therapies during normothermic ex vivo lung perfusion

Author

Listed:
  • Marcos Galasso

    (Toronto General Research Institute, University Health Network)

  • Jordan J. Feld

    (University Health Network, Toronto General Hospital)

  • Yui Watanabe

    (Toronto General Research Institute, University Health Network)

  • Mauricio Pipkin

    (Toronto General Research Institute, University Health Network)

  • Cara Summers

    (Toronto General Research Institute, University Health Network)

  • Aadil Ali

    (Toronto General Research Institute, University Health Network)

  • Robert Qaqish

    (Toronto General Research Institute, University Health Network)

  • Manyin Chen

    (Toronto General Research Institute, University Health Network)

  • Rafaela V. P. Ribeiro

    (Toronto General Research Institute, University Health Network)

  • Khaled Ramadan

    (Toronto General Research Institute, University Health Network)

  • Layla Pires

    (Toronto General Research Institute, University Health Network)

  • Vanderlei S. Bagnato

    (São Carlos Institute of Physics, University of São Paulo Brazil)

  • Cristina Kurachi

    (São Carlos Institute of Physics, University of São Paulo Brazil)

  • Vera Cherepanov

    (University Health Network, Toronto General Hospital)

  • Gray Moonen

    (Toronto General Research Institute, University Health Network)

  • Anajara Gazzalle

    (Toronto General Research Institute, University Health Network)

  • Thomas K. Waddell

    (Toronto General Research Institute, University Health Network)

  • Mingyao Liu

    (Toronto General Research Institute, University Health Network)

  • Shaf Keshavjee

    (Toronto General Research Institute, University Health Network)

  • Brian C. Wilson

    (University of Toronto)

  • Atul Humar

    (University Health Network)

  • Marcelo Cypel

    (Toronto General Research Institute, University Health Network
    University Health Network)

Abstract

Availability of organs is a limiting factor for lung transplantation, leading to substantial mortality rates on the wait list. Use of organs from donors with transmissible viral infections, such as hepatitis C virus (HCV), would increase organ donation, but these organs are generally not offered for transplantation due to a high risk of transmission. Here, we develop a method for treatment of HCV-infected human donor lungs that prevents HCV transmission. Physical viral clearance in combination with germicidal light-based therapies during normothermic ex-vivo Lung Perfusion (EVLP), a method for assessment and treatment of injured donor lungs, inactivates HCV virus in a short period of time. Such treatment is shown to be safe using a large animal EVLP-to-lung transplantation model. This strategy of treating viral infection in a donor organ during preservation could significantly increase the availability of organs for transplantation and encourages further clinical development.

Suggested Citation

  • Marcos Galasso & Jordan J. Feld & Yui Watanabe & Mauricio Pipkin & Cara Summers & Aadil Ali & Robert Qaqish & Manyin Chen & Rafaela V. P. Ribeiro & Khaled Ramadan & Layla Pires & Vanderlei S. Bagnato , 2019. "Inactivating hepatitis C virus in donor lungs using light therapies during normothermic ex vivo lung perfusion," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-018-08261-z
    DOI: 10.1038/s41467-018-08261-z
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