IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v10y2019i1d10.1038_s41467-018-08256-w.html
   My bibliography  Save this article

A brain-wide functional map of the serotonergic responses to acute stress and fluoxetine

Author

Listed:
  • Joanes Grandjean

    (Agency for Science Technology and Research
    Neuroscience Center Zurich
    University of Zurich and ETH Zurich)

  • Alberto Corcoba

    (University of Lausanne)

  • Martin C. Kahn

    (University of Zurich Hospital for Psychiatry
    University of Oxford)

  • A. Louise Upton

    (University of Oxford
    University of Oxford)

  • Evan S. Deneris

    (Case Western Reserve University School of Medicine)

  • Erich Seifritz

    (Neuroscience Center Zurich
    University of Zurich Hospital for Psychiatry)

  • Fritjof Helmchen

    (Neuroscience Center Zurich
    University of Zurich)

  • Isabelle M. Mansuy

    (Department of Health Science and Technology of ETH Zürich)

  • Edward O. Mann

    (University of Oxford
    University of Oxford)

  • Markus Rudin

    (Neuroscience Center Zurich
    University of Zurich and ETH Zurich
    University of Zurich)

  • Bechara J. Saab

    (Neuroscience Center Zurich
    University of Zurich Hospital for Psychiatry
    Mobio Interactive)

Abstract

Central serotonin (5-HT) orchestrates myriad cognitive processes and lies at the core of many stress-related psychiatric illnesses. However, the basic relationship between its brain-wide axonal projections and functional dynamics is not known. Here we combine optogenetics and fMRI to produce a brain-wide 5-HT evoked functional map. We find that DRN photostimulation leads to an increase in the hemodynamic response in the DRN itself, while projection areas predominately exhibit a reduction of cerebral blood volume mirrored by suppression of cortical delta oscillations. We find that the regional distribution of post-synaptically expressed 5-HT receptors better correlates with DRN 5-HT functional connectivity than anatomical projections. Our work suggests that neuroarchitecture is not the primary determinant of function for the DRN 5-HT. With respect to two 5-HT elevating stimuli, we find that acute stress leads to circuit-wide blunting of the DRN output, while the SSRI fluoxetine noticeably enhances DRN functional connectivity. These data provide fundamental insight into the brain-wide functional dynamics of the 5-HT projection system.

Suggested Citation

  • Joanes Grandjean & Alberto Corcoba & Martin C. Kahn & A. Louise Upton & Evan S. Deneris & Erich Seifritz & Fritjof Helmchen & Isabelle M. Mansuy & Edward O. Mann & Markus Rudin & Bechara J. Saab, 2019. "A brain-wide functional map of the serotonergic responses to acute stress and fluoxetine," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-018-08256-w
    DOI: 10.1038/s41467-018-08256-w
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-018-08256-w
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-018-08256-w?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Gabriel Desrosiers-Grégoire & Gabriel A. Devenyi & Joanes Grandjean & M. Mallar Chakravarty, 2024. "A standardized image processing and data quality platform for rodent fMRI," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-018-08256-w. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.