IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v10y2019i1d10.1038_s41467-018-08143-4.html
   My bibliography  Save this article

Time-dependent assessment of stimulus-evoked regional dopamine release

Author

Listed:
  • Rachel N. Lippert

    (Max Planck Institute for Metabolism Research)

  • Anna Lena Cremer

    (Max Planck Institute for Metabolism Research)

  • Sharmili Edwin Thanarajah

    (Max Planck Institute for Metabolism Research
    University Hospital of Cologne)

  • Clio Korn

    (University of Oxford, Warneford Hospital
    University of Oxford)

  • Thomas Jahans-Price

    (University of Oxford)

  • Lauren M. Burgeno

    (University of Oxford)

  • Marc Tittgemeyer

    (Max Planck Institute for Metabolism Research
    Joseph-Stelzmann-Str. 26
    290 Congress Avenue)

  • Jens C. Brüning

    (Max Planck Institute for Metabolism Research
    Joseph-Stelzmann-Str. 26
    University Hospital of Cologne)

  • Mark E. Walton

    (University of Oxford
    University of Oxford)

  • Heiko Backes

    (Max Planck Institute for Metabolism Research)

Abstract

To date, the spatiotemporal release of specific neurotransmitters at physiological levels in the human brain cannot be detected. Here, we present a method that relates minute-by-minute fluctuations of the positron emission tomography (PET) radioligand [11C]raclopride directly to subsecond dopamine release events. We show theoretically that synaptic dopamine release induces low frequency temporal variations of extrasynaptic extracellular dopamine levels, at time scales of one minute, that can evoke detectable temporal variations in the [11C]raclopride signal. Hence, dopaminergic activity can be monitored via temporal fluctuations in the [11C]raclopride PET signal. We validate this theory using fast-scan cyclic voltammetry and [11C]raclopride PET in mice during chemogenetic activation of dopaminergic neurons. We then apply the method to data from human subjects given a palatable milkshake and discover immediate and—for the first time—delayed food-induced dopamine release. This method enables time-dependent regional monitoring of stimulus-evoked dopamine release at physiological levels.

Suggested Citation

  • Rachel N. Lippert & Anna Lena Cremer & Sharmili Edwin Thanarajah & Clio Korn & Thomas Jahans-Price & Lauren M. Burgeno & Marc Tittgemeyer & Jens C. Brüning & Mark E. Walton & Heiko Backes, 2019. "Time-dependent assessment of stimulus-evoked regional dopamine release," Nature Communications, Nature, vol. 10(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-018-08143-4
    DOI: 10.1038/s41467-018-08143-4
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-018-08143-4
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-018-08143-4?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-018-08143-4. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.