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Dissecting the circuit for blindsight to reveal the critical role of pulvinar and superior colliculus

Author

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  • Masaharu Kinoshita

    (National Institute for Physiological Sciences
    Hirosaki University School of Medicine)

  • Rikako Kato

    (National Institute for Physiological Sciences
    Kyoto University)

  • Kaoru Isa

    (National Institute for Physiological Sciences
    Kyoto University)

  • Kenta Kobayashi

    (National Institute for Physiological Sciences
    the Graduate University of Advanced Studies (SOKENDAI))

  • Kazuto Kobayashi

    (Fukushima Medical University)

  • Hirotaka Onoe

    (Kyoto University
    RIKEN Center for Life Science Technologies (CLST))

  • Tadashi Isa

    (National Institute for Physiological Sciences
    Kyoto University
    National Institute for Physiological Sciences
    the Graduate University of Advanced Studies (SOKENDAI))

Abstract

In patients with damage to the primary visual cortex (V1), residual vision can guide goal-directed movements to targets in the blind field without awareness. This phenomenon has been termed blindsight, and its neural mechanisms are controversial. There should be visual pathways to the higher visual cortices bypassing V1, however some literature propose that the signal is mediated by the superior colliculus (SC) and pulvinar, while others claim the dorsal lateral geniculate nucleus (dLGN) transmits the signal. Here, we directly test the role of SC to ventrolateral pulvinar (vlPul) pathway in blindsight monkeys. Pharmacological inactivation of vlPul impairs visually guided saccades (VGS) in the blind field. Selective and reversible blockade of the SC-vlPul pathway by combining two viral vectors also impairs VGS. With these results we claim the SC-vlPul pathway contributes to blindsight. The discrepancy would be due to the extent of retrograde degeneration of dLGN and task used for assessment.

Suggested Citation

  • Masaharu Kinoshita & Rikako Kato & Kaoru Isa & Kenta Kobayashi & Kazuto Kobayashi & Hirotaka Onoe & Tadashi Isa, 2019. "Dissecting the circuit for blindsight to reveal the critical role of pulvinar and superior colliculus," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-018-08058-0
    DOI: 10.1038/s41467-018-08058-0
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