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LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores

Author

Listed:
  • Min Wu

    (National Center of Biomedical Analysis)

  • Yan Chang

    (National Center of Biomedical Analysis)

  • Huaibin Hu

    (National Center of Biomedical Analysis)

  • Rui Mu

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Yucheng Zhang

    (National Center of Biomedical Analysis)

  • Xuanhe Qin

    (National Center of Biomedical Analysis)

  • Xiaotao Duan

    (Beijing Institute of Pharmacology and Toxicology)

  • Weihua Li

    (National Center of Biomedical Analysis)

  • Haiqing Tu

    (National Center of Biomedical Analysis)

  • Weina Zhang

    (National Center of Biomedical Analysis)

  • Guang Wang

    (National Center of Biomedical Analysis)

  • Qiuying Han

    (National Center of Biomedical Analysis)

  • Ailing Li

    (National Center of Biomedical Analysis)

  • Tao Zhou

    (National Center of Biomedical Analysis)

  • Kazuhiro Iwai

    (Kyoto University)

  • Xuemin Zhang

    (National Center of Biomedical Analysis)

  • Huiyan Li

    (National Center of Biomedical Analysis
    Fudan University)

Abstract

Faithful chromosome segregation requires proper chromosome congression at prometaphase and dynamic maintenance of the aligned chromosomes at metaphase. Chromosome missegregation can result in aneuploidy, birth defects and cancer. The kinetochore-bound KMN network and the kinesin motor CENP-E are critical for kinetochore-microtubule attachment and chromosome stability. The linear ubiquitin chain assembly complex (LUBAC) attaches linear ubiquitin chains to substrates, with well-established roles in immune response. Here, we identify LUBAC as a key player of chromosome alignment during mitosis. LUBAC catalyzes linear ubiquitination of the kinetochore motor CENP-E, which is specifically required for the localization of CENP-E at attached kinetochores, but not unattached ones. KNL1 acts as a receptor of linear ubiquitin chains to anchor CENP-E at attached kinetochores in prometaphase and metaphase. Thus, linear ubiquitination promotes chromosome congression and dynamic chromosome alignment by coupling the dynamic kinetochore microtubule receptor CENP-E to the static one, the KMN network.

Suggested Citation

  • Min Wu & Yan Chang & Huaibin Hu & Rui Mu & Yucheng Zhang & Xuanhe Qin & Xiaotao Duan & Weihua Li & Haiqing Tu & Weina Zhang & Guang Wang & Qiuying Han & Ailing Li & Tao Zhou & Kazuhiro Iwai & Xuemin Z, 2019. "LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores," Nature Communications, Nature, vol. 10(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-018-08043-7
    DOI: 10.1038/s41467-018-08043-7
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    Cited by:

    1. Yesheng Fu & Lei Li & Xin Zhang & Zhikang Deng & Ying Wu & Wenzhe Chen & Yuchen Liu & Shan He & Jian Wang & Yuping Xie & Zhiwei Tu & Yadi Lyu & Yange Wei & Shujie Wang & Chun-Ping Cui & Cui Hua Liu & , 2024. "Systematic HOIP interactome profiling reveals critical roles of linear ubiquitination in tissue homeostasis," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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