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Post-exposure immunotherapy for two ebolaviruses and Marburg virus in nonhuman primates

Author

Listed:
  • Jennifer M. Brannan

    (US Army Medical Research Institute of Infectious Diseases)

  • Shihua He

    (Public Health Agency of Canada)

  • Katie A. Howell

    (Integrated BioTherapeutics, Inc.)

  • Laura I. Prugar

    (US Army Medical Research Institute of Infectious Diseases)

  • Wenjun Zhu

    (Public Health Agency of Canada)

  • Hong Vu

    (Integrated BioTherapeutics, Inc.)

  • Sergey Shulenin

    (Integrated BioTherapeutics, Inc.)

  • Shweta Kailasan

    (Integrated BioTherapeutics, Inc.)

  • Henna Raina

    (Integrated BioTherapeutics, Inc.)

  • Gary Wong

    (Public Health Agency of Canada
    University of Manitoba)

  • Md Niaz Rahim

    (Public Health Agency of Canada
    University of Manitoba)

  • Logan Banadyga

    (Public Health Agency of Canada)

  • Kevin Tierney

    (Public Health Agency of Canada)

  • Xuelian Zhao

    (University of Maryland School of Medicine)

  • Yuxing Li

    (University of Maryland School of Medicine
    University of Maryland)

  • Frederick W. Holtsberg

    (Integrated BioTherapeutics, Inc.)

  • John M. Dye

    (US Army Medical Research Institute of Infectious Diseases)

  • Xiangguo Qiu

    (Public Health Agency of Canada
    University of Manitoba)

  • M. Javad Aman

    (Integrated BioTherapeutics, Inc.)

Abstract

The 2013–2016 Ebola virus (EBOV) disease epidemic demonstrated the grave consequences of filovirus epidemics in the absence of effective therapeutics. Besides EBOV, two additional ebolaviruses, Sudan (SUDV) and Bundibugyo (BDBV) viruses, as well as multiple variants of Marburg virus (MARV), have also caused high fatality epidemics. Current experimental EBOV monoclonal antibodies (mAbs) are ineffective against SUDV, BDBV, or MARV. Here, we report that a cocktail of two broadly neutralizing ebolavirus mAbs, FVM04 and CA45, protects nonhuman primates (NHPs) against EBOV and SUDV infection when delivered four days post infection. This cocktail when supplemented by the anti-MARV mAb MR191 exhibited 100% efficacy in MARV-infected NHPs. These findings provide a solid foundation for clinical development of broadly protective immunotherapeutics for use in future filovirus epidemics.

Suggested Citation

  • Jennifer M. Brannan & Shihua He & Katie A. Howell & Laura I. Prugar & Wenjun Zhu & Hong Vu & Sergey Shulenin & Shweta Kailasan & Henna Raina & Gary Wong & Md Niaz Rahim & Logan Banadyga & Kevin Tierne, 2019. "Post-exposure immunotherapy for two ebolaviruses and Marburg virus in nonhuman primates," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-018-08040-w
    DOI: 10.1038/s41467-018-08040-w
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