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A region-resolved mucosa proteome of the human stomach

Author

Listed:
  • Xiaotian Ni

    (The Fifth Medical Center, General Hospital of PLA
    National Center for Protein Sciences (The PHOENIX Center, Beijing), Institute of lifeomics
    East China Normal University)

  • Zhaoli Tan

    (The Fifth Medical Center, General Hospital of PLA)

  • Chen Ding

    (National Center for Protein Sciences (The PHOENIX Center, Beijing), Institute of lifeomics
    Institutes of Biomedical Sciences, School of Life Sciences, Zhongshan Hospital, Fudan University)

  • Chunchao Zhang

    (Baylor College of Medicine)

  • Lan Song

    (National Center for Protein Sciences (The PHOENIX Center, Beijing), Institute of lifeomics
    Hebei University)

  • Shuai Yang

    (The Fifth Medical Center, General Hospital of PLA)

  • Mingwei Liu

    (National Center for Protein Sciences (The PHOENIX Center, Beijing), Institute of lifeomics)

  • Ru Jia

    (The Fifth Medical Center, General Hospital of PLA)

  • Chuanhua Zhao

    (The Fifth Medical Center, General Hospital of PLA)

  • Lei Song

    (National Center for Protein Sciences (The PHOENIX Center, Beijing), Institute of lifeomics)

  • Wanlin Liu

    (National Center for Protein Sciences (The PHOENIX Center, Beijing), Institute of lifeomics)

  • Quan Zhou

    (National Center for Protein Sciences (The PHOENIX Center, Beijing), Institute of lifeomics)

  • Tongqing Gong

    (National Center for Protein Sciences (The PHOENIX Center, Beijing), Institute of lifeomics)

  • Xianju Li

    (National Center for Protein Sciences (The PHOENIX Center, Beijing), Institute of lifeomics)

  • Yanhong Tai

    (The Fifth Medical Center, General Hospital of PLA)

  • Weimin Zhu

    (National Center for Protein Sciences (The PHOENIX Center, Beijing), Institute of lifeomics)

  • Tieliu Shi

    (East China Normal University)

  • Yi Wang

    (National Center for Protein Sciences (The PHOENIX Center, Beijing), Institute of lifeomics
    Baylor College of Medicine)

  • Jianming Xu

    (The Fifth Medical Center, General Hospital of PLA)

  • Bei Zhen

    (National Center for Protein Sciences (The PHOENIX Center, Beijing), Institute of lifeomics)

  • Jun Qin

    (National Center for Protein Sciences (The PHOENIX Center, Beijing), Institute of lifeomics
    Institutes of Biomedical Sciences, School of Life Sciences, Zhongshan Hospital, Fudan University
    Baylor College of Medicine)

Abstract

The human gastric mucosa is the most active layer of the stomach wall, involved in food digestion, metabolic processes and gastric carcinogenesis. Anatomically, the human stomach is divided into seven regions, but the protein basis for cellular specialization is not well understood. Here we present a global analysis of protein profiles of 82 apparently normal mucosa samples obtained from living individuals by endoscopic stomach biopsy. We identify 6,258 high-confidence proteins and estimate the ranges of protein expression in the seven stomach regions, presenting a region-resolved proteome reference map of the near normal, human stomach. Furthermore, we measure mucosa protein profiles of tumor and tumor nearby tissues (TNT) from 58 gastric cancer patients, enabling comparisons between tumor, TNT, and normal tissue. These datasets provide a rich resource for the gastrointestinal tract research community to investigate the molecular basis for region-specific functions in mucosa physiology and pathology including gastric cancer.

Suggested Citation

  • Xiaotian Ni & Zhaoli Tan & Chen Ding & Chunchao Zhang & Lan Song & Shuai Yang & Mingwei Liu & Ru Jia & Chuanhua Zhao & Lei Song & Wanlin Liu & Quan Zhou & Tongqing Gong & Xianju Li & Yanhong Tai & Wei, 2019. "A region-resolved mucosa proteome of the human stomach," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-018-07960-x
    DOI: 10.1038/s41467-018-07960-x
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    Cited by:

    1. Yangzi Chen & Bohong Wang & Yizi Zhao & Xinxin Shao & Mingshuo Wang & Fuhai Ma & Laishou Yang & Meng Nie & Peng Jin & Ke Yao & Haibin Song & Shenghan Lou & Hang Wang & Tianshu Yang & Yantao Tian & Pen, 2024. "Metabolomic machine learning predictor for diagnosis and prognosis of gastric cancer," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Lingling Li & Dongxian Jiang & Qiao Zhang & Hui Liu & Fujiang Xu & Chunmei Guo & Zhaoyu Qin & Haixing Wang & Jinwen Feng & Yang Liu & Weijie Chen & Xue Zhang & Lin Bai & Sha Tian & Subei Tan & Chen Xu, 2023. "Integrative proteogenomic characterization of early esophageal cancer," Nature Communications, Nature, vol. 14(1), pages 1-28, December.
    3. Lingling Li & Dongxian Jiang & Hui Liu & Chunmei Guo & Rui Zhao & Qiao Zhang & Chen Xu & Zhaoyu Qin & Jinwen Feng & Yang Liu & Haixing Wang & Weijie Chen & Xue Zhang & Bin Li & Lin Bai & Sha Tian & Su, 2023. "Comprehensive proteogenomic characterization of early duodenal cancer reveals the carcinogenesis tracks of different subtypes," Nature Communications, Nature, vol. 14(1), pages 1-24, December.

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