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Structure of BAI1/ELMO2 complex reveals an action mechanism of adhesion GPCRs via ELMO family scaffolds

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  • Zhuangfeng Weng

    (University of Chinese Academy of Sciences
    ShanghaiTech University)

  • Chenghao Situ

    (Hong Kong University of Science and Technology, Kowloon)

  • Lin Lin

    (University of Chinese Academy of Sciences)

  • Zhenguo Wu

    (Hong Kong University of Science and Technology, Kowloon)

  • Jinwei Zhu

    (University of Chinese Academy of Sciences)

  • Rongguang Zhang

    (University of Chinese Academy of Sciences
    ShanghaiTech University)

Abstract

The brain-specific angiogenesis inhibitor (BAI) subfamily of adhesion G protein-coupled receptors (aGPCRs) plays crucial roles in diverse cellular processes including phagocytosis, myoblast fusion, and synaptic development through the ELMO/DOCK/Rac signaling pathway, although the underlying molecular mechanism is not well understood. Here, we demonstrate that an evolutionarily conserved fragment located in the C-terminal cytoplasmic tail of BAI-aGPCRs is specifically recognized by the RBD-ARR-ELMO (RAE) supramodule of the ELMO family scaffolds. The crystal structures of ELMO2-RAE and its complex with BAI1 uncover the molecular basis of BAI/ELMO interactions. Based on the complex structure we identify aGPCR-GPR128 as another upstream receptor for the ELMO family scaffolds, most likely with a recognition mode similar to that of BAI/ELMO interactions. Finally, we map disease-causing mutations of BAI and ELMO and analyze their effects on complex formation.

Suggested Citation

  • Zhuangfeng Weng & Chenghao Situ & Lin Lin & Zhenguo Wu & Jinwei Zhu & Rongguang Zhang, 2019. "Structure of BAI1/ELMO2 complex reveals an action mechanism of adhesion GPCRs via ELMO family scaffolds," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-018-07938-9
    DOI: 10.1038/s41467-018-07938-9
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    Cited by:

    1. Viviane Tran & Sarah Nahlé & Amélie Robert & Inès Desanlis & Ryan Killoran & Sophie Ehresmann & Marie-Pier Thibault & David Barford & Kodi S. Ravichandran & Martin Sauvageau & Matthew J. Smith & Marie, 2022. "Biasing the conformation of ELMO2 reveals that myoblast fusion can be exploited to improve muscle regeneration," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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