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RETRACTED ARTICLE: A switch in the poly(dC)/RmlB complex regulates bacterial persister formation

Author

Listed:
  • Xu Chen

    (Nanjing Agricultural University)

  • Gen Li

    (Nanjing Agricultural University)

  • Xuewei Liao

    (Nanjing Normal University)

  • Jie Fang

    (Nanjing Agricultural University)

  • Bo Li

    (Nanjing Agricultural University)

  • Shanshan Yu

    (Nanjing Agricultural University)

  • Mingming Sun

    (Nanjing Agricultural University)

  • Jun Wu

    (Nanjing Agricultural University)

  • Lihao Zhang

    (Nanjing Agricultural University)

  • Yi Hu

    (Nanjing Agricultural University)

  • Jiaguo Jiao

    (Nanjing Agricultural University)

  • Ting Liu

    (Nanjing Agricultural University)

  • Li Xu

    (Nanjing Agricultural University)

  • Xiaoyun Chen

    (Nanjing Agricultural University)

  • Manqiang Liu

    (Nanjing Agricultural University
    Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization
    Jiangsu Key Laboratory for Solid Organic Waste Utilization)

  • Huixin Li

    (Nanjing Agricultural University)

  • Feng Hu

    (Nanjing Agricultural University)

  • Kouhong Sun

    (Zoonbio Biotechnology Co., Ltd)

Abstract

Bacterial persisters are phenotypic variants that tolerate exposure to lethal antibiotics. These dormant cells are responsible for chronic and recurrent infections. Multiple mechanisms have been linked to persister formation. Here, we report that a complex, consisting of an extracellular poly(dC) and its membrane-associated binding protein RmlB, appears to be associated with persistence of the opportunistic pathogen Pseudomonas aeruginosa. Environmental stimuli triggers a switch in the complex physiological state (from poly(dC)/RmlB to P-poly(dC)/RmlB or RmlB). In response to the switch, bacteria decrease proton motive force and intracellular ATP levels, forming dormant cells. This alteration in complex status is linked to a (p)ppGpp-controlled signaling pathway that includes inorganic polyphosphate, Lon protease, exonuclease VII (XseA/XseB), and the type III secretion system. The persistence might be also an adaptive response to the lethal action of the dTDP-l-rhamnose pathway shutdown, which occurs due to switching of poly(dC)/RmlB.

Suggested Citation

  • Xu Chen & Gen Li & Xuewei Liao & Jie Fang & Bo Li & Shanshan Yu & Mingming Sun & Jun Wu & Lihao Zhang & Yi Hu & Jiaguo Jiao & Ting Liu & Li Xu & Xiaoyun Chen & Manqiang Liu & Huixin Li & Feng Hu & Kou, 2019. "RETRACTED ARTICLE: A switch in the poly(dC)/RmlB complex regulates bacterial persister formation," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-018-07861-z
    DOI: 10.1038/s41467-018-07861-z
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