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Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides

Author

Listed:
  • Rachel H. Clare

    (Liverpool School of Tropical Medicine)

  • Catherine Bardelle

    (AstraZeneca)

  • Paul Harper

    (AstraZeneca)

  • W. David Hong

    (University of Liverpool)

  • Ulf Börjesson

    (AstraZeneca)

  • Kelly L. Johnston

    (Liverpool School of Tropical Medicine)

  • Matthew Collier

    (AstraZeneca)

  • Laura Myhill

    (Liverpool School of Tropical Medicine)

  • Andrew Cassidy

    (Liverpool School of Tropical Medicine)

  • Darren Plant

    (AstraZeneca)

  • Helen Plant

    (AstraZeneca)

  • Roger Clark

    (AstraZeneca)

  • Darren A. N. Cook

    (Liverpool School of Tropical Medicine)

  • Andrew Steven

    (Liverpool School of Tropical Medicine)

  • John Archer

    (Liverpool School of Tropical Medicine)

  • Paul McGillan

    (University of Liverpool)

  • Sitthivut Charoensutthivarakul

    (Liverpool School of Tropical Medicine)

  • Jaclyn Bibby

    (University of Liverpool)

  • Raman Sharma

    (Liverpool School of Tropical Medicine)

  • Gemma L. Nixon

    (University of Liverpool)

  • Barton E. Slatko

    (New England Biolabs, Inc)

  • Lindsey Cantin

    (New England Biolabs, Inc)

  • Bo Wu

    (New England Biolabs, Inc)

  • Joseph Turner

    (Liverpool School of Tropical Medicine)

  • Louise Ford

    (Liverpool School of Tropical Medicine)

  • Kirsty Rich

    (AstraZeneca)

  • Mark Wigglesworth

    (AstraZeneca)

  • Neil G. Berry

    (University of Liverpool)

  • Paul M. O’Neill

    (University of Liverpool)

  • Mark J. Taylor

    (Liverpool School of Tropical Medicine)

  • Stephen A. Ward

    (Liverpool School of Tropical Medicine)

Abstract

Nematodes causing lymphatic filariasis and onchocerciasis rely on their bacterial endosymbiont, Wolbachia, for survival and fecundity, making Wolbachia a promising therapeutic target. Here we perform a high-throughput screen of AstraZeneca’s 1.3 million in-house compound library and identify 5 novel chemotypes with faster in vitro kill rates (

Suggested Citation

  • Rachel H. Clare & Catherine Bardelle & Paul Harper & W. David Hong & Ulf Börjesson & Kelly L. Johnston & Matthew Collier & Laura Myhill & Andrew Cassidy & Darren Plant & Helen Plant & Roger Clark & Da, 2019. "Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides," Nature Communications, Nature, vol. 10(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-018-07826-2
    DOI: 10.1038/s41467-018-07826-2
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