IDEAS home Printed from https://ideas.repec.org/a/jss/jstsof/v056i09.html
   My bibliography  Save this article

POBE: A Computer Program for Optimal Design of Multi-Subject Blocked fMRI Experiments

Author

Listed:
  • Maus, Bärbel
  • van Breukelen, Gerard

Abstract

For functional magnetic resonance imaging (fMRI) studies, researchers can use multi-subject blocked designs to identify active brain regions for a certain stimulus type of interest. Before performing such an experiment, careful planning is necessary to obtain efficient stimulus effect estimators within the available financial resources. The optimal number of subjects and the optimal scanning time for a multi-subject blocked design with fixed experimental costs can be determined using optimal design methods. In this paper, the user-friendly computer program POBE 1.2 (program for optimal design of blocked experiments, version 1.2) is presented. POBE provides a graphical user interface for fMRI researchers to easily and efficiently design their experiments. The computer program POBE calculates the optimal number of subjects and the optimal scanning time for user specified experimental factors and model parameters so that the statistical efficiency is maximised for a given study budget. POBE can also be used to determine the minimum budget for a given power. Furthermore, a maximin design can be determined as efficient design for a possible range of values for the unknown model parameters. In this paper, the computer program is described and illustrated with typical experimental factors for a blocked fMRI experiment.

Suggested Citation

  • Maus, Bärbel & van Breukelen, Gerard, 2014. "POBE: A Computer Program for Optimal Design of Multi-Subject Blocked fMRI Experiments," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 56(i09).
    • Handle: RePEc:jss:jstsof:v:056:i09
    DOI: http://hdl.handle.net/10.18637/jss.v056.i09
    as

    Download full text from publisher

    File URL: https://www.jstatsoft.org/index.php/jss/article/view/v056i09/v56i09.pdf
    Download Restriction: no
    File URL: https://www.jstatsoft.org/index.php/jss/article/downloadSuppFile/v056i09/POBE_Version1.2.zip
    Download Restriction: no
    File URL: https://libkey.io/http://hdl.handle.net/10.18637/jss.v056.i09?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Kao, Ming-Hung, 2009. "Multi-Objective Optimal Experimental Designs for ER-fMRI Using MATLAB," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 30(i11).
    2. Mihălcescu Cezar & Sion Beatrice, 2013. "Modeling And Optimizing The Business Processes Using Microsoft Office Excel," Romanian Economic Business Review, Romanian-American University, vol. 7(2), pages 414-421, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Beatrice Sion & Patricia Dodu & Andreea Rozalia Manoliu, 2017. "The Impact Of Technology On Promoting Travel And Leisure Services In The 21st Century," Romanian Economic Business Review, Romanian-American University, vol. 12(1), pages 28-34, March.
    2. Holger Dette & Laura Hoyden & Sonja Kuhnt & Kirsten Schorning, 2017. "Optimal designs for thermal spraying," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 66(1), pages 53-72, January.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:jss:jstsof:v:056:i09. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Christopher F. Baum (email available below). General contact details of provider: http://www.jstatsoft.org/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.