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An Artificial Intelligence Approach to Thrombophilia Risk

Author

Listed:
  • João Vilhena

    (Universidade de Évora, Évora, Portugal)

  • Henrique Vicente

    (Universidade de Évora, Évora, Portugal)

  • M. Rosário Martins

    (Universidade de Évora, Évora, Portugal)

  • José Grañeda

    (Hospital do Espírito Santo de Évora, Évora, Portugal)

  • Filomena Caldeira

    (Hospital do Espírito Santo de Évora, Évora, Portugal)

  • Rodrigo Gusmão

    (Hospital do Espírito Santo de Évora, Évora, Portugal)

  • João Neves

    (Drs. Nicolas & Asp, Dubai, UAE)

  • José Neves

    (Universidade do Minho, Braga, Portugal)

Abstract

Thrombophilia stands for a genetic or an acquired tendency to hypercoagulable states, frequently as venous thrombosis. Venous thromboembolism, represented mainly by deep venous thrombosis and pulmonary embolism, is often a chronic illness, associated with high morbidity and mortality. Therefore, it is crucial to identify the cause of the disease, the most appropriate treatment, the length of treatment or prevent a thrombotic recurrence. This work will focus on the development of a diagnosis decision support system in terms of a formal agenda built on a Logic Programming approach to knowledge representation and reasoning, complemented with a computational framework based on Artificial Neural Networks. The proposed model has been quite accurate in the assessment of thrombophilia predisposition (accuracy close to 95%). Furthermore, the model classified properly the patients that really presented the pathology, as well as classifying the disease absence (sensitivity and specificity higher than 95%).

Suggested Citation

  • João Vilhena & Henrique Vicente & M. Rosário Martins & José Grañeda & Filomena Caldeira & Rodrigo Gusmão & João Neves & José Neves, 2017. "An Artificial Intelligence Approach to Thrombophilia Risk," International Journal of Reliable and Quality E-Healthcare (IJRQEH), IGI Global, vol. 6(2), pages 49-69, April.
  • Handle: RePEc:igg:jrqeh0:v:6:y:2017:i:2:p:49-69
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